%0 Journal Article
%A Upadhyaya, Santhosh A
%A Robinson, Giles
%A Onar-Thomas, Arzu
%A Orr, Brent A
%A Johann, Pascal
%A Wu, Gang
%A Billups, Catherine A
%A Tatevossian, Ruth G
%A Dhanda, Sandeep Kumar
%A Srinivasan, Ashok
%A Broniscer, Alberto
%A Qaddoumi, Ibrahim
%A Vinitsky, Anna
%A Armstrong, Gregory T
%A Bendel, Anne
%A Hassall, Timothy Eg
%A Partap, Sonia
%A Fisher, Paul G
%A Crawford, John R
%A Chintagumpala, Murali M
%A Bouffet, Eric
%A Gururangan, Sridharan
%A Mostafavi, Roya
%A Sanders, Robert P
%A Klimo, Paul
%A Patay, Zoltan
%A Indelicato, Daniel J
%A Nichols, Kim E
%A Boop, Frederick A
%A Merchant, Thomas E
%A Kool, Marcel
%A Ellison, David W
%A Gajjar, Amar
%T Relevance of Molecular Groups in Children with Newly Diagnosed Atypical Teratoid Rhabdoid Tumor: Results from Prospective St. Jude Multi-Institutional Trials.
%J Clinical cancer research
%V 27
%N 10
%@ 1557-3265
%C Philadelphia, Pa. [u.a.]
%I AACR
%M DKFZ-2021-00673
%P 2879-2889
%D 2021
%Z 27(10):2879-2889
%X Report relevance of molecular groups to clinico-pathologic features, germline SMARCB1/SMARCA4 alterations (GLA), and survival of children with atypical teratoid rhabdoid tumor (ATRT) treated in two multi-institutional clinical trials.Seventy-four participants with newly diagnosed ATRT were treated in two trials: infants (SJYC07: age<3 years; n=52) and children (SJMB03: age 3-21 years; n=22), using surgery, conventional chemotherapy (infants), or dose-dense chemotherapy with autologous stem cell rescue (children), and age- and risk-adapted radiation therapy [focal (infants) and craniospinal (CSI) (children)]. Molecular groups ATRT-MYC (MYC), ATRT-SHH (SHH), and ATRT-TYR (TYR) were determined from tumor DNA methylation profiles.Twenty-four participants (32
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:33737307
%R 10.1158/1078-0432.CCR-20-4731
%U https://inrepo02.dkfz.de/record/168085