TY  - JOUR
AU  - Upadhyaya, Santhosh A
AU  - Robinson, Giles
AU  - Onar-Thomas, Arzu
AU  - Orr, Brent A
AU  - Johann, Pascal
AU  - Wu, Gang
AU  - Billups, Catherine A
AU  - Tatevossian, Ruth G
AU  - Dhanda, Sandeep Kumar
AU  - Srinivasan, Ashok
AU  - Broniscer, Alberto
AU  - Qaddoumi, Ibrahim
AU  - Vinitsky, Anna
AU  - Armstrong, Gregory T
AU  - Bendel, Anne
AU  - Hassall, Timothy Eg
AU  - Partap, Sonia
AU  - Fisher, Paul G
AU  - Crawford, John R
AU  - Chintagumpala, Murali M
AU  - Bouffet, Eric
AU  - Gururangan, Sridharan
AU  - Mostafavi, Roya
AU  - Sanders, Robert P
AU  - Klimo, Paul
AU  - Patay, Zoltan
AU  - Indelicato, Daniel J
AU  - Nichols, Kim E
AU  - Boop, Frederick A
AU  - Merchant, Thomas E
AU  - Kool, Marcel
AU  - Ellison, David W
AU  - Gajjar, Amar
TI  - Relevance of Molecular Groups in Children with Newly Diagnosed Atypical Teratoid Rhabdoid Tumor: Results from Prospective St. Jude Multi-Institutional Trials.
JO  - Clinical cancer research
VL  - 27
IS  - 10
SN  - 1557-3265
CY  - Philadelphia, Pa. [u.a.]
PB  - AACR
M1  - DKFZ-2021-00673
SP  - 2879-2889
PY  - 2021
N1  - 27(10):2879-2889
AB  - Report relevance of molecular groups to clinico-pathologic features, germline SMARCB1/SMARCA4 alterations (GLA), and survival of children with atypical teratoid rhabdoid tumor (ATRT) treated in two multi-institutional clinical trials.Seventy-four participants with newly diagnosed ATRT were treated in two trials: infants (SJYC07: age<3 years; n=52) and children (SJMB03: age 3-21 years; n=22), using surgery, conventional chemotherapy (infants), or dose-dense chemotherapy with autologous stem cell rescue (children), and age- and risk-adapted radiation therapy [focal (infants) and craniospinal (CSI) (children)]. Molecular groups ATRT-MYC (MYC), ATRT-SHH (SHH), and ATRT-TYR (TYR) were determined from tumor DNA methylation profiles.Twenty-four participants (32
LB  - PUB:(DE-HGF)16
C6  - pmid:33737307
DO  - DOI:10.1158/1078-0432.CCR-20-4731
UR  - https://inrepo02.dkfz.de/record/168085
ER  -