Home > Publications database > ZFTA-translocations constitute ependymoma chromatin remodeling and transcription factors. > print

001     168090
005     20240229133557.0
024 7 _ |a 10.1158/2159-8290.CD-20-1052
|2 doi
024 7 _ |a pmid:33741711
|2 pmid
024 7 _ |a 2159-8274
|2 ISSN
024 7 _ |a 2159-8290
|2 ISSN
024 7 _ |a altmetric:102183765
|2 altmetric
037 _ _ |a DKFZ-2021-00678
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Kupp, Robert
|b 0
245 _ _ |a ZFTA-translocations constitute ependymoma chromatin remodeling and transcription factors.
260 _ _ |a Philadelphia, Pa.
|c 2021
336 7 _ |a article
|2 DRIVER
336 7 _ |a Output Types/Journal article
|2 DataCite
336 7 _ |a Journal Article
|b journal
|m journal
|0 PUB:(DE-HGF)16
|s 1634297907_1826
|2 PUB:(DE-HGF)
336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a JOURNAL_ARTICLE
|2 ORCID
336 7 _ |a Journal Article
|0 0
|2 EndNote
500 _ _ |a 2021 Sep;11(9):2216-2229
520 _ _ |a ZFTA (C11orf95)-a gene of unknown function-partners with a variety of transcriptional co-activators in translocations that drive supratentorial ependymoma, a frequently lethal brain tumor. Understanding the function of ZFTA is key to developing therapies that inhibit these fusion proteins. Here, using a combination of transcriptomics, chromatin immunoprecipitation-sequencing, and proteomics, we interrogated a series of deletion-mutant genes to identify a tri-partite transformation mechanism of ZFTA-containing fusions, including: spontaneous nuclear translocation, extensive chromatin binding, and SWI/SNF, SAGA and NuA4/Tip60 HAT chromatin modifier complex recruitment. Thereby, ZFTA tethers fusion proteins across the genome, modifying chromatin to an active state, and enabling its partner transcriptional co-activators to promote promiscuous expression of a transforming transcriptome. Using mouse models, we validate further those elements of ZFTA-fusion proteins that are critical for transformation-including ZFTA zinc fingers and partner gene transactivation domains-thereby unmasking vulnerabilities for therapeutic targeting.
536 _ _ |a 312 - Funktionelle und strukturelle Genomforschung (POF4-312)
|0 G:(DE-HGF)POF4-312
|c POF4-312
|f POF IV
|x 0
588 _ _ |a Dataset connected to CrossRef, PubMed,
700 1 _ |a Ruff, Lisa
|b 1
700 1 _ |a Terranova, Sabrina
|b 2
700 1 _ |a Nathan, Erica
|b 3
700 1 _ |a Ballereau, Stephane
|0 0000-0002-8479-3110
|b 4
700 1 _ |a Stark, Rory
|0 0000-0002-1790-5469
|b 5
700 1 _ |a Sekhar Reddy Chilamakuri, Chandra
|b 6
700 1 _ |a Hoffmann, Nadin
|b 7
700 1 _ |a Wickham-Rahrmann, Katherine
|b 8
700 1 _ |a Widdess, Marcus
|b 9
700 1 _ |a Arabzade, Amir
|b 10
700 1 _ |a Zhao, Yanhua
|b 11
700 1 _ |a Varadharajan, Srinidhi
|0 0000-0002-2033-0758
|b 12
700 1 _ |a Zheng, Tuyu
|0 P:(DE-He78)1d5e6252296473fc060b71e61a22256c
|b 13
|u dkfz
700 1 _ |a Murugesan, Mohankumar K
|b 14
700 1 _ |a Pfister, Stefan
|0 P:(DE-He78)f746aa965c4e1af518b016de3aaff5d9
|b 15
|u dkfz
700 1 _ |a Kawauchi, Daisuke
|b 16
700 1 _ |a Pajtler, Kristian W
|0 P:(DE-He78)a7c1bbac024fa232d9c6b78443328d9d
|b 17
|u dkfz
700 1 _ |a Deneen, Benjamin
|b 18
700 1 _ |a Mack, Stephen C
|0 0000-0001-9620-4742
|b 19
700 1 _ |a Masih, Katherine E
|0 0000-0002-0809-668X
|b 20
700 1 _ |a Gryder, Berkley E
|0 0000-0003-0130-2302
|b 21
700 1 _ |a Khan, Javed
|b 22
700 1 _ |a Gilbertson, Richard J
|0 0000-0001-7539-9472
|b 23
773 _ _ |a 10.1158/2159-8290.CD-20-1052
|g p. candisc.1052.2020 -
|0 PERI:(DE-600)2607892-2
|n 9
|p 2216-2229
|t Cancer discovery
|v 11
|y 2021
|x 2159-8290
909 C O |p VDB
|o oai:inrepo02.dkfz.de:168090
910 1 _ |a Deutsches Krebsforschungszentrum
|0 I:(DE-588b)2036810-0
|k DKFZ
|b 13
|6 P:(DE-He78)1d5e6252296473fc060b71e61a22256c
910 1 _ |a Deutsches Krebsforschungszentrum
|0 I:(DE-588b)2036810-0
|k DKFZ
|b 15
|6 P:(DE-He78)f746aa965c4e1af518b016de3aaff5d9
910 1 _ |a Deutsches Krebsforschungszentrum
|0 I:(DE-588b)2036810-0
|k DKFZ
|b 17
|6 P:(DE-He78)a7c1bbac024fa232d9c6b78443328d9d
913 1 _ |a DE-HGF
|b Gesundheit
|l Krebsforschung
|1 G:(DE-HGF)POF4-310
|0 G:(DE-HGF)POF4-312
|3 G:(DE-HGF)POF4
|2 G:(DE-HGF)POF4-300
|4 G:(DE-HGF)POF
|v Funktionelle und strukturelle Genomforschung
|x 0
913 0 _ |a DE-HGF
|b Gesundheit
|l Krebsforschung
|1 G:(DE-HGF)POF3-310
|0 G:(DE-HGF)POF3-312
|3 G:(DE-HGF)POF3
|2 G:(DE-HGF)POF3-300
|4 G:(DE-HGF)POF
|v Functional and structural genomics
|x 0
914 1 _ |y 2021
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0200
|2 StatID
|b SCOPUS
|d 2021-01-31
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0300
|2 StatID
|b Medline
|d 2021-01-31
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0199
|2 StatID
|b Clarivate Analytics Master Journal List
|d 2021-01-31
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0160
|2 StatID
|b Essential Science Indicators
|d 2021-01-31
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1050
|2 StatID
|b BIOSIS Previews
|d 2021-01-31
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1190
|2 StatID
|b Biological Abstracts
|d 2021-01-31
915 _ _ |a WoS
|0 StatID:(DE-HGF)0113
|2 StatID
|b Science Citation Index Expanded
|d 2021-01-31
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0150
|2 StatID
|b Web of Science Core Collection
|d 2021-01-31
915 _ _ |a JCR
|0 StatID:(DE-HGF)0100
|2 StatID
|b CANCER DISCOV : 2019
|d 2021-01-31
915 _ _ |a IF >= 25
|0 StatID:(DE-HGF)9925
|2 StatID
|b CANCER DISCOV : 2019
|d 2021-01-31
920 1 _ |0 I:(DE-He78)B062-20160331
|k B062
|l B062 Pädiatrische Neuroonkologie
|x 0
920 1 _ |0 I:(DE-He78)HD01-20160331
|k HD01
|l DKTK HD zentral
|x 1
980 _ _ |a journal
980 _ _ |a VDB
980 _ _ |a I:(DE-He78)B062-20160331
980 _ _ |a I:(DE-He78)HD01-20160331
980 _ _ |a UNRESTRICTED

LibraryCollectionCLSMajorCLSMinorLanguageAuthor
Marc 21