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000168091 1001_ $$aArabzade, Amir$$b0
000168091 245__ $$aZFTA-RELA Dictates Oncogenic Transcriptional Programs to Drive Aggressive Supratentorial Ependymoma.
000168091 260__ $$aPhiladelphia, Pa.$$c2021
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000168091 520__ $$aOver 60% of supratentorial (ST) ependymomas harbor a ZFTA-RELA (ZRfus) gene fusion (formerly C11orf95-RELA). To study the biology of ZRfus, we developed an autochthonous mouse tumor model using in utero electroporation (IUE) of the embryonic mouse brain. Integrative epigenomic and transcriptomic mapping was performed on IUE driven ZRfus tumors by CUT&RUN, ChIP, ATAC, and RNA sequencing and compared to human ZRfus driven ependymoma. In addition to direct canonical NF-kB pathway activation, ZRfus dictates a neoplastic transcriptional program and binds to thousands of unique sites across the genome that are enriched with Plagl family transcription factor (TF) motifs. ZRfus activates gene expression programs through recruitment of transcriptional co-activators (Brd4, Ep300, Cbp, Pol2) that are amenable to pharmacologic inhibition. Downstream ZRfus target genes converge on developmental programs marked by Plagl transcription factor proteins, and activate neoplastic programs enriched in Mapk, focal adhesion, and gene imprinting networks.
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000168091 7001_ $$aZhao, Yanhua$$b1
000168091 7001_ $$00000-0002-2033-0758$$aVaradharajan, Srinidhi$$b2
000168091 7001_ $$00000-0002-7505-6119$$aChen, Hsiao-Chi$$b3
000168091 7001_ $$00000-0003-4192-6523$$aJessa, Selin$$b4
000168091 7001_ $$aRivas, Bryan$$b5
000168091 7001_ $$00000-0002-5938-7495$$aStuckert, Austin J$$b6
000168091 7001_ $$aSolis, Minerva$$b7
000168091 7001_ $$aKardian, Alisha$$b8
000168091 7001_ $$00000-0002-0060-8070$$aTlais, Dana$$b9
000168091 7001_ $$aGolbourn, Brian J$$b10
000168091 7001_ $$aStanton, Ann-Catherine J$$b11
000168091 7001_ $$aChan, Yuen San$$b12
000168091 7001_ $$aOlson, Calla$$b13
000168091 7001_ $$aKarlin, Kristen L$$b14
000168091 7001_ $$aKong, Kathleen$$b15
000168091 7001_ $$aKupp, Robert$$b16
000168091 7001_ $$00000-0002-2737-6871$$aHu, Baoli$$b17
000168091 7001_ $$00000-0002-6389-369X$$aInjac, Sarah G$$b18
000168091 7001_ $$00000-0003-3610-6475$$aNgo, Madeline$$b19
000168091 7001_ $$aWang, Peter R$$b20
000168091 7001_ $$aDe Leon, Luz A$$b21
000168091 7001_ $$0P:(DE-He78)a1f4b408b9155beb2a8f7cba4d04fe88$$aSahm, Felix$$b22$$udkfz
000168091 7001_ $$0P:(DE-He78)0ac2bd1a9fb1823a351ee4434d80808b$$aKawauchi, Daisuke$$b23$$udkfz
000168091 7001_ $$0P:(DE-He78)f746aa965c4e1af518b016de3aaff5d9$$aPfister, Stefan$$b24$$udkfz
000168091 7001_ $$aLin, Charles Y$$b25
000168091 7001_ $$00000-0003-4441-497X$$aHodges, H Courtney$$b26
000168091 7001_ $$aSingh, Irtisha$$b27
000168091 7001_ $$aWestbrook, Thomas F$$b28
000168091 7001_ $$aChintagumpala, Murali M$$b29
000168091 7001_ $$aBlaney, Susan M$$b30
000168091 7001_ $$aParsons, Donald W$$b31
000168091 7001_ $$0P:(DE-He78)a7c1bbac024fa232d9c6b78443328d9d$$aPajtler, Kristian W$$b32$$udkfz
000168091 7001_ $$aAgnihotri, Sameer$$b33
000168091 7001_ $$00000-0001-7539-9472$$aGilbertson, Richard J$$b34
000168091 7001_ $$aYi, Joanna$$b35
000168091 7001_ $$aJabado, Nada$$b36
000168091 7001_ $$00000-0002-5158-7126$$aKleinman, Claudia L$$b37
000168091 7001_ $$aBertrand, Kelsey C$$b38
000168091 7001_ $$aDeneen, Benjamin$$b39
000168091 7001_ $$00000-0001-9620-4742$$aMack, Stephen C$$b40
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