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@ARTICLE{Arabzade:168091,
      author       = {A. Arabzade and Y. Zhao and S. Varadharajan and H.-C. Chen
                      and S. Jessa and B. Rivas and A. J. Stuckert and M. Solis
                      and A. Kardian and D. Tlais and B. J. Golbourn and A. J.
                      Stanton and Y. S. Chan and C. Olson and K. L. Karlin and K.
                      Kong and R. Kupp and B. Hu and S. G. Injac and M. Ngo and P.
                      R. Wang and L. A. De Leon and F. Sahm$^*$ and D.
                      Kawauchi$^*$ and S. Pfister$^*$ and C. Y. Lin and H. C.
                      Hodges and I. Singh and T. F. Westbrook and M. M.
                      Chintagumpala and S. M. Blaney and D. W. Parsons and K. W.
                      Pajtler$^*$ and S. Agnihotri and R. J. Gilbertson and J. Yi
                      and N. Jabado and C. L. Kleinman and K. C. Bertrand and B.
                      Deneen and S. C. Mack},
      title        = {{ZFTA}-{RELA} {D}ictates {O}ncogenic {T}ranscriptional
                      {P}rograms to {D}rive {A}ggressive {S}upratentorial
                      {E}pendymoma.},
      journal      = {Cancer discovery},
      volume       = {11},
      number       = {9},
      issn         = {2159-8290},
      address      = {Philadelphia, Pa.},
      reportid     = {DKFZ-2021-00679},
      pages        = {2200-2215},
      year         = {2021},
      note         = {2021 Sep;11(9):2200-2215},
      abstract     = {Over $60\%$ of supratentorial (ST) ependymomas harbor a
                      ZFTA-RELA (ZRfus) gene fusion (formerly C11orf95-RELA). To
                      study the biology of ZRfus, we developed an autochthonous
                      mouse tumor model using in utero electroporation (IUE) of
                      the embryonic mouse brain. Integrative epigenomic and
                      transcriptomic mapping was performed on IUE driven ZRfus
                      tumors by $CUT\&RUN,$ ChIP, ATAC, and RNA sequencing and
                      compared to human ZRfus driven ependymoma. In addition to
                      direct canonical NF-kB pathway activation, ZRfus dictates a
                      neoplastic transcriptional program and binds to thousands of
                      unique sites across the genome that are enriched with Plagl
                      family transcription factor (TF) motifs. ZRfus activates
                      gene expression programs through recruitment of
                      transcriptional co-activators (Brd4, Ep300, Cbp, Pol2) that
                      are amenable to pharmacologic inhibition. Downstream ZRfus
                      target genes converge on developmental programs marked by
                      Plagl transcription factor proteins, and activate neoplastic
                      programs enriched in Mapk, focal adhesion, and gene
                      imprinting networks.},
      cin          = {B062 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)B062-20160331 / I:(DE-He78)HD01-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33741710},
      doi          = {10.1158/2159-8290.CD-20-1066},
      url          = {https://inrepo02.dkfz.de/record/168091},
}