TY  - JOUR
AU  - Ellingjord-Dale, Merete
AU  - Christakoudi, Sofia
AU  - Weiderpass, Elisabete
AU  - Panico, Salvatore
AU  - Dossus, Laure
AU  - Olsen, Anja
AU  - Tjønneland, Anne
AU  - Kaaks, Rudolf
AU  - Schulze, Matthias B
AU  - Masala, Giovanna
AU  - Gram, Inger T
AU  - Skeie, Guri
AU  - Rosendahl, Ann H
AU  - Sund, Malin
AU  - Key, Tim
AU  - Ferrari, Pietro
AU  - Gunter, Marc
AU  - Heath, Alicia K
AU  - Tsilidis, Konstantinos K
AU  - Riboli, Elio
TI  - Long-term weight change and risk of breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) study.
JO  - International journal of epidemiology
VL  - 50
IS  - 6
SN  - 1464-3685
CY  - Oxford
PB  - Oxford Univ. Press
M1  - DKFZ-2021-00698
SP  - 1914–1926
PY  - 2021
N1  - Volume 50, Issue 6, December 2021, Pages 1914–1926
AB  - The role of obesity and weight change in breast-cancer development is complex and incompletely understood. We investigated long-term weight change and breast-cancer risk by body mass index (BMI) at age 20 years, menopausal status, hormone replacement therapy (HRT) and hormone-receptor status.Using data on weight collected at three different time points from women who participated in the European Prospective Investigation into Cancer and Nutrition (EPIC) study, we investigated the association between weight change from age 20 years until middle adulthood and risk of breast cancer.In total, 150 257 women with a median age of 51 years at cohort entry were followed for an average of 14 years (standard deviation = 3.9) during which 6532 breast-cancer cases occurred. Compared with women with stable weight (±2.5 kg), long-term weight gain >10 kg was positively associated with postmenopausal breast-cancer risk in women who were lean at age 20 [hazard ratio (HR) = 1.42; 95
KW  - breast cancer (Other)
KW  - cohort study (Other)
KW  - long-term weight change (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:33755122
DO  - DOI:10.1093/ije/dyab032
UR  - https://inrepo02.dkfz.de/record/168130
ER  -