TY  - JOUR
AU  - Amadou, Amina
AU  - Freisling, Heinz
AU  - Jenab, Mazda
AU  - Tsilidis, Konstantinos K
AU  - Trichopoulou, Antonia
AU  - Boffetta, Paolo
AU  - Van Guelpen, Bethany
AU  - Mokoroa, Olatz
AU  - Wilsgaard, Tom
AU  - Kee, Frank
AU  - Schöttker, Ben
AU  - Ordóñez-Mena, José M
AU  - Männistö, Satu
AU  - Söderberg, Stefan
AU  - Vermeulen, Roel C H
AU  - Quirós, J Ramón
AU  - Liao, Linda M
AU  - Sinha, Rashmi
AU  - Kuulasmaa, Kari
AU  - Brenner, Hermann
AU  - Romieu, Isabelle
TI  - Prevalent diabetes and risk of total, colorectal, prostate and breast cancers in an ageing population: meta-analysis of individual participant data from cohorts of the CHANCES consortium.
JO  - British journal of cancer
VL  - 124
IS  - 11
SN  - 1532-1827
CY  - Edinburgh
PB  - Nature Publ. Group
M1  - DKFZ-2021-00730
SP  - 1882-1890
PY  - 2021
N1  - 2021 May;124(11):1882-1890
AB  - We investigated whether associations between prevalent diabetes and cancer risk are pertinent to older adults and whether associations differ across subgroups of age, body weight status or levels of physical activity.We harmonised data from seven prospective cohort studies of older individuals in Europe and the United States participating in the CHANCES consortium. Cox proportional hazard regression was used to estimate the associations of prevalent diabetes with cancer risk (all cancers combined, and for colorectum, prostate and breast). We calculated summary risk estimates across cohorts using pooled analysis and random-effects meta-analysis.A total of 667,916 individuals were included with an overall median (P25-P75) age at recruitment of 62.3 (57-67) years. During a median follow-up time of 10.5 years, 114,404 total cancer cases were ascertained. Diabetes was not associated with the risk of all cancers combined (hazard ratio (HR) = 0.94; 95
LB  - PUB:(DE-HGF)16
C6  - pmid:33772152
DO  - DOI:10.1038/s41416-021-01347-4
UR  - https://inrepo02.dkfz.de/record/168190
ER  -