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@ARTICLE{Amadou:168190,
      author       = {A. Amadou and H. Freisling and M. Jenab and K. K. Tsilidis
                      and A. Trichopoulou and P. Boffetta and B. Van Guelpen and
                      O. Mokoroa and T. Wilsgaard and F. Kee and B. Schöttker$^*$
                      and J. M. Ordóñez-Mena and S. Männistö and S. Söderberg
                      and R. C. H. Vermeulen and J. R. Quirós and L. M. Liao and
                      R. Sinha and K. Kuulasmaa and H. Brenner$^*$ and I. Romieu},
      title        = {{P}revalent diabetes and risk of total, colorectal,
                      prostate and breast cancers in an ageing population:
                      meta-analysis of individual participant data from cohorts of
                      the {CHANCES} consortium.},
      journal      = {British journal of cancer},
      volume       = {124},
      number       = {11},
      issn         = {1532-1827},
      address      = {Edinburgh},
      publisher    = {Nature Publ. Group},
      reportid     = {DKFZ-2021-00730},
      pages        = {1882-1890},
      year         = {2021},
      note         = {2021 May;124(11):1882-1890},
      abstract     = {We investigated whether associations between prevalent
                      diabetes and cancer risk are pertinent to older adults and
                      whether associations differ across subgroups of age, body
                      weight status or levels of physical activity.We harmonised
                      data from seven prospective cohort studies of older
                      individuals in Europe and the United States participating in
                      the CHANCES consortium. Cox proportional hazard regression
                      was used to estimate the associations of prevalent diabetes
                      with cancer risk (all cancers combined, and for colorectum,
                      prostate and breast). We calculated summary risk estimates
                      across cohorts using pooled analysis and random-effects
                      meta-analysis.A total of 667,916 individuals were included
                      with an overall median (P25-P75) age at recruitment of 62.3
                      (57-67) years. During a median follow-up time of 10.5 years,
                      114,404 total cancer cases were ascertained. Diabetes was
                      not associated with the risk of all cancers combined (hazard
                      ratio (HR) = 0.94; $95\%$ confidence interval (CI):
                      0.86-1.04; I2 = $63.3\%).$ Diabetes was positively
                      associated with colorectal cancer risk in men (HR = 1.17;
                      $95\%$ CI: 1.08-1.26; I2 = $0\%)$ and a similar HR in women
                      (1.13; $95\%$ CI: 0.82-1.56; I2 = $46\%),$ but with a
                      confidence interval including the null. Diabetes was
                      inversely associated with prostate cancer risk (HR = 0.81;
                      $95\%$ CI: 0.77-0.85; I2 = $0\%),$ but not with
                      postmenopausal breast cancer (HR = 0.96; $95\%$ CI:
                      0.89-1.03; I2 = $0\%).$ In exploratory subgroup analyses,
                      diabetes was inversely associated with prostate cancer risk
                      only in men with overweight or obesity.Prevalent diabetes
                      was positively associated with colorectal cancer risk and
                      inversely associated with prostate cancer risk in older
                      Europeans and Americans.},
      cin          = {C070 / C120 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)C120-20160331 /
                      I:(DE-He78)HD01-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33772152},
      doi          = {10.1038/s41416-021-01347-4},
      url          = {https://inrepo02.dkfz.de/record/168190},
}