TY  - JOUR
AU  - Aglago, Elom K
AU  - Schalkwijk, Casper G
AU  - Freisling, Heinz
AU  - Fedirko, Veronika
AU  - Hughes, David J
AU  - Jiao, Li
AU  - Dahm, Christina C
AU  - Olsen, Anja
AU  - Tjønneland, Anne
AU  - Katzke, Verena
AU  - Johnson, Theron
AU  - Schulze, Matthias B
AU  - Aleksandrova, Krasimira
AU  - Masala, Giovanna
AU  - Sieri, Sabina
AU  - Simeon, Vittorio
AU  - Tumino, Rosario
AU  - Macciotta, Alessandra
AU  - Bueno-de-Mesquita, Bas
AU  - Skeie, Guri
AU  - Gram, Inger Torhild
AU  - Sandanger, Torkjel
AU  - Jakszyn, Paula
AU  - Sánchez, Maria-Jose
AU  - Amiano, Pilar
AU  - Colorado-Yohar, Sandra M
AU  - Gurrea, Aurelio Barricarte
AU  - Perez-Cornago, Aurora
AU  - Mayén, Ana-Lucia
AU  - Weiderpass, Elisabete
AU  - Gunter, Marc J
AU  - Heath, Alicia K
AU  - Jenab, Mazda
TI  - Plasma concentrations of advanced glycation end-products and colorectal cancer risk in the EPIC study.
JO  - Carcinogenesis
VL  - 42
IS  - 5
SN  - 1460-2180
CY  - Oxford
PB  - Oxford Univ. Press
M1  - DKFZ-2021-00733
SP  - 705-713
PY  - 2021
N1  - 2021 May 28;42(5):705-713
AB  - Advanced glycation end-products (AGEs) are a heterogeneous group of compounds formed by the non-enzymatic reaction between amino-acids and reducing sugars, or dicarbonyls as intermediate compounds. Experimental studies suggest that AGEs may promote colorectal cancer, but prospective epidemiologic studies are inconclusive. We conducted a case-control study nested within a large European cohort. Plasma concentrations of three protein-bound AGEs: N ε-(carboxy-methyl)lysine (CML), N ε-(carboxy-ethyl)lysine (CEL) and N δ-(5-hydro-5-methyl-4-imidazolon-2-yl)-ornithine (MG-H1) were measured by ultra-performance liquid chromatography tandem mass-spectrometry in baseline samples collected from 1,378 incident primary colorectal cancer cases and 1,378 matched controls. Multivariable-adjusted odds ratios (ORs) and 95
KW  - Advanced glycation end-product (Other)
KW  - colorectal cancer (Other)
KW  - glycotoxin (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:33780524
DO  - DOI:10.1093/carcin/bgab026
UR  - https://inrepo02.dkfz.de/record/168193
ER  -