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@ARTICLE{Koerber:168283,
      author       = {S. A. Koerber and J. Boesch and C. Kratochwil$^*$ and I.
                      Schlampp and J. Ristau and E. Winter and S. Zschaebitz and
                      L. Hofer and K. Herfarth and K. Kopka$^*$ and T.
                      Holland-Letz$^*$ and D. Jaeger and M. Hohenfellner and U.
                      Haberkorn$^*$ and J. Debus$^*$ and F. Giesel$^*$},
      title        = {{P}redicting the {R}isk of {M}etastases by
                      {PSMA}-{PET}/{CT}-{E}valuation of 335 {M}en with
                      {T}reatment-{N}aïve {P}rostate {C}arcinoma.},
      journal      = {Cancers},
      volume       = {13},
      number       = {7},
      issn         = {2072-6694},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DKFZ-2021-00794},
      pages        = {1508},
      year         = {2021},
      note         = {#LA:E060#},
      abstract     = {Men diagnosed with aggressive prostate cancer are at high
                      risk of local relapse or systemic progression after
                      definitive treatment. Treatment intensification is highly
                      needed for that patient cohort; however, no relevant
                      stratification tool has been implemented into the clinical
                      work routine so far. Therefore, the aim of the current study
                      was to analyze the role of initial PSMA-PET/CT as a
                      prediction tool for metastases. In total, 335 men with
                      biopsy-proven prostate carcinoma and PSMA-PET/CT for primary
                      staging were enrolled in the present, retrospective study.
                      The number and site of metastases were analyzed and
                      correlated with the maximum standardized uptake value
                      (SUVmax) of the intraprostatic, malignant lesion. Receiver
                      operating characteristic (ROC) curves were used to determine
                      sensitivity and specificity and a model was created using
                      multiple logistic regression. PSMA-PET/CT detected 171
                      metastases with PSMA-uptake in 82 patients. A statistically
                      significant higher SUVmax was found for men with metastatic
                      disease than for the cohort without distant metastases
                      (median 16.1 vs. 11.2; p < 0.001). The area under the curve
                      (AUC) in regard to predicting the presence of any metastases
                      was 0.65. Choosing a cut-off value of 11.9 for SUVmax, a
                      sensitivity and specificity (factor 1:1) of $76.0\%$ and
                      $58.4\%$ was obtained. The current study confirms, that
                      initial PSMA-PET/CT is able to detect a relatively high
                      number of treatment-naïve men with metastatic prostate
                      carcinoma. Intraprostatic SUVmax seems to be a promising
                      parameter for the prediction of distant disease and could be
                      used for treatment stratification-aspects which should be
                      verified within prospective trials.},
      keywords     = {PET (Other) / PSMA (Other) / intraprostatic SUV (Other) /
                      metastases (Other) / prostate cancer (Other)},
      cin          = {E060 / DD01 / C060 / HD01 / E050},
      ddc          = {610},
      cid          = {I:(DE-He78)E060-20160331 / I:(DE-He78)DD01-20160331 /
                      I:(DE-He78)C060-20160331 / I:(DE-He78)HD01-20160331 /
                      I:(DE-He78)E050-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33805971},
      doi          = {10.3390/cancers13071508},
      url          = {https://inrepo02.dkfz.de/record/168283},
}