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@ARTICLE{Andres:168285,
      author       = {M. Andres and A. Feller and V. Arndt$^*$ and T. N. W.
                      Group},
      title        = {{T}rends of incidence, mortality and survival for chronic
                      lymphocytic leukaemia / small lymphocytic lymphoma in
                      {S}witzerland between 1997 and 2016: a population-based
                      study.},
      journal      = {Swiss medical weekly},
      volume       = {151},
      issn         = {0036-7672},
      address      = {Basel},
      publisher    = {EMH Schweizerischer Ärzteverl.},
      reportid     = {DKFZ-2021-00796},
      pages        = {w20463},
      year         = {2021},
      abstract     = {During the last 20 years, treatment for chronic lymphocytic
                      leukaemia (CLL) / small lymphocytic lymphoma (SLL) has
                      advanced, with improved clinical outcomes in randomised
                      controlled trials. Currently, no data have been published
                      from Switzerland to assess effectiveness of recent
                      healthcare advances in CLL/SLL on a population-based level.
                      We aimed to estimate trends in incidence, mortality and
                      survival for patients with CLL/SLL in Switzerland.We
                      retrospectively studied registry data from the National
                      Agency for Cancer Registration (NACR) database in
                      Switzerland from 1997 to 2016. We investigated incidence,
                      mortality and survival in consecutive 5-year periods.
                      Age-specific rates were calculated for three age groups (<65
                      years, $65\&ndash;74$ years and $\&ge;75$ years).We obtained
                      6301 cases with CLL/SLL. Median age at diagnosis was 72
                      years. From 7.0 per 100,000 person-years in
                      $1997\&ndash;2002,$ age-adjusted incidence rates peaked at
                      7.8 per 100,000 person-years in the second time period,
                      $2002\&ndash;2006,$ and declined afterwards to 6.4 per
                      100,000 person-years in $2012\&ndash;2016.$ Mortality
                      declined from 2.4 per 100,000 person-years in
                      $1997\&ndash;2002$ to 2.0 per 100,000 in $2012\&ndash;2016.$
                      Five- and 10-year age-standardised relative survival
                      increased from $77.9\%$ and $55.6\%,$ respectively, in
                      $1997\&ndash;2001$ to $83.6\%$ (p = 0.009) and $64.2\%$ (p =
                      0.005), respectively, in $2012\&ndash;2016.$ Improvement in
                      age-specific relative survival was only significant in the
                      middle age group $(65\&ndash;74$ years). Incidence and
                      mortality were significantly higher in males. Females had
                      better relative survival.We found no clear down- or upward
                      trend in age-adjusted incidence rates. Age-standardised
                      survival improved over time, mainly in the two younger
                      age-groups, but this improvement was statistically
                      significant in those aged $65\&ndash;74$ years only. Males
                      have higher incidence rates, higher mortality and shorter
                      survival than females. Reporting delay and underreporting
                      are major limitations in the interpretation of registry data
                      from patients diagnosed with CLL/SLL.},
      cin          = {C071},
      ddc          = {610},
      cid          = {I:(DE-He78)C071-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33793959},
      doi          = {10.4414/smw.2021.20463},
      url          = {https://inrepo02.dkfz.de/record/168285},
}