%0 Journal Article
%A Erben, Vanessa
%A Poschet, Gernot
%A Schrotz-King, Petra
%A Brenner, Hermann
%T Comparing Metabolomics Profiles in Various Types of Liquid Biopsies among Screening Participants with and without Advanced Colorectal Neoplasms.
%J Diagnostics
%V 11
%N 3
%@ 2075-4418
%C Basel
%I MDPI
%M DKFZ-2021-00810
%P 561
%D 2021
%Z #EA:C120#LA:C070#
%X Analysis of metabolomics has been suggested as a promising approach for early detection of colorectal cancer and advanced adenomas. We investigated and compared the metabolomics profile in blood, stool, and urine samples of screening colonoscopy participants and aimed to evaluate differences in metabolite concentrations between people with advanced colorectal neoplasms and those without neoplasms. Various types of bio-samples (plasma, feces, and urine) from 400 participants of screening colonoscopy were investigated using the MxP® Quant 500 kit (Biocrates, Innsbruck, Austria). We detected a broad range of metabolites in blood, stool, and urine samples (504, 331, and 131, respectively). Significant correlations were found between concentrations in blood and stool, blood and urine, and stool and urine for 93, 154, and 102 metabolites, of which 68 (73
%K colorectal neoplasms (Other)
%K feces (Other)
%K liquid biopsy (Other)
%K metabolomics (Other)
%K plasma (Other)
%K urine (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:33804777
%R 10.3390/diagnostics11030561
%U https://inrepo02.dkfz.de/record/168299