TY  - JOUR
AU  - Erben, Vanessa
AU  - Poschet, Gernot
AU  - Schrotz-King, Petra
AU  - Brenner, Hermann
TI  - Comparing Metabolomics Profiles in Various Types of Liquid Biopsies among Screening Participants with and without Advanced Colorectal Neoplasms.
JO  - Diagnostics
VL  - 11
IS  - 3
SN  - 2075-4418
CY  - Basel
PB  - MDPI
M1  - DKFZ-2021-00810
SP  - 561
PY  - 2021
N1  - #EA:C120#LA:C070#
AB  - Analysis of metabolomics has been suggested as a promising approach for early detection of colorectal cancer and advanced adenomas. We investigated and compared the metabolomics profile in blood, stool, and urine samples of screening colonoscopy participants and aimed to evaluate differences in metabolite concentrations between people with advanced colorectal neoplasms and those without neoplasms. Various types of bio-samples (plasma, feces, and urine) from 400 participants of screening colonoscopy were investigated using the MxP® Quant 500 kit (Biocrates, Innsbruck, Austria). We detected a broad range of metabolites in blood, stool, and urine samples (504, 331, and 131, respectively). Significant correlations were found between concentrations in blood and stool, blood and urine, and stool and urine for 93, 154, and 102 metabolites, of which 68 (73
KW  - colorectal neoplasms (Other)
KW  - feces (Other)
KW  - liquid biopsy (Other)
KW  - metabolomics (Other)
KW  - plasma (Other)
KW  - urine (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:33804777
DO  - DOI:10.3390/diagnostics11030561
UR  - https://inrepo02.dkfz.de/record/168299
ER  -