% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Erben:168299,
      author       = {V. Erben$^*$ and G. Poschet and P. Schrotz-King$^*$ and H.
                      Brenner$^*$},
      title        = {{C}omparing {M}etabolomics {P}rofiles in {V}arious {T}ypes
                      of {L}iquid {B}iopsies among {S}creening {P}articipants with
                      and without {A}dvanced {C}olorectal {N}eoplasms.},
      journal      = {Diagnostics},
      volume       = {11},
      number       = {3},
      issn         = {2075-4418},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DKFZ-2021-00810},
      pages        = {561},
      year         = {2021},
      note         = {#EA:C120#LA:C070#},
      abstract     = {Analysis of metabolomics has been suggested as a promising
                      approach for early detection of colorectal cancer and
                      advanced adenomas. We investigated and compared the
                      metabolomics profile in blood, stool, and urine samples of
                      screening colonoscopy participants and aimed to evaluate
                      differences in metabolite concentrations between people with
                      advanced colorectal neoplasms and those without neoplasms.
                      Various types of bio-samples (plasma, feces, and urine) from
                      400 participants of screening colonoscopy were investigated
                      using the MxP® Quant 500 kit (Biocrates, Innsbruck,
                      Austria). We detected a broad range of metabolites in blood,
                      stool, and urine samples (504, 331, and 131, respectively).
                      Significant correlations were found between concentrations
                      in blood and stool, blood and urine, and stool and urine for
                      93, 154, and 102 metabolites, of which 68 $(73\%),$ 126
                      $(82\%),$ and 39 $(38\%)$ were positive correlations. We
                      found significant differences between participants with and
                      without advanced colorectal neoplasms for concentrations of
                      123, 49, and 28 metabolites in blood, stool and urine
                      samples, respectively. We detected mostly positive
                      correlations between metabolite concentrations in blood
                      samples and urine or stool samples, and mostly negative
                      correlations between urine and stool samples. Differences
                      between subjects with and without advanced colorectal
                      neoplasms were found for metabolite concentrations in each
                      of the three bio-fluids.},
      keywords     = {colorectal neoplasms (Other) / feces (Other) / liquid
                      biopsy (Other) / metabolomics (Other) / plasma (Other) /
                      urine (Other)},
      cin          = {C120 / C070 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)C120-20160331 / I:(DE-He78)C070-20160331 /
                      I:(DE-He78)HD01-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33804777},
      doi          = {10.3390/diagnostics11030561},
      url          = {https://inrepo02.dkfz.de/record/168299},
}