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@ARTICLE{Sachpekidis:168300,
      author       = {C. Sachpekidis$^*$ and J. C. Hassel and A.
                      Kopp-Schneider$^*$ and U. Haberkorn$^*$ and A.
                      Dimitrakopoulou-Strauss$^*$},
      title        = {{Q}uantitative {D}ynamic 18{F}-{FDG} {PET}/{CT} in
                      {S}urvival {P}rediction of {M}etastatic {M}elanoma under
                      {PD}-1 {I}nhibitors.},
      journal      = {Cancers},
      volume       = {13},
      number       = {5},
      issn         = {2072-6694},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DKFZ-2021-00811},
      pages        = {1019},
      year         = {2021},
      note         = {#EA:E060#LA:E060#},
      abstract     = {The advent of novel immune checkpoint inhibitors has led to
                      unprecedented survival rates in advanced melanoma. At the
                      same time, it has raised relevant challenges in the
                      interpretation of treatment response by conventional imaging
                      approaches. In the present prospective study, we explored
                      the predictive role of quantitative, dynamic
                      18F-fluorodeoxyglucose (18F-FDG) positron emission
                      tomography/computed tomography (PET/CT) performed early
                      during immunotherapy in metastatic melanoma patients
                      receiving treatment with programmed cell death protein 1
                      (PD-1) inhibitors. Twenty-five patients under PD-1 blockade
                      underwent dynamic and static 18F-FDG PET/CT before the start
                      of treatment (baseline PET/CT) and after the initial two
                      cycles of therapy (interim PET/CT). The impact of
                      semiquantitatively (standardized uptake value, SUV) and
                      quantitatively (based on compartment modeling and fractal
                      analysis) derived PET/CT parameters, both from melanoma
                      lesions and different reference tissues, on progression-free
                      survival (PFS) was analyzed. At a median follow-up of 24.2
                      months, survival analysis revealed that the interim PET/CT
                      parameters SUVmean, SUVmax and fractal dimension (FD) of the
                      hottest melanoma lesions adversely affected PFS, while the
                      parameters FD of the thyroid, as well as SUVmax and k3 of
                      the bone marrow positively affected PFS. The herein
                      presented findings highlight the potential predictive role
                      of quantitative, dynamic, interim PET/CT in metastatic
                      melanoma under PD-1 blockade. Therefore, dynamic PET/CT
                      could be performed in selected oncological cases in
                      combination with static, whole-body PET/CT in order to
                      enhance the diagnostic certainty offered by conventional
                      imaging and yield additional information regarding specific
                      molecular and pathophysiological mechanisms involved in
                      tumor biology and response to treatment.},
      keywords     = {18F-FDG (Other) / PD-1 inhibitors (Other) / SUV (Other) /
                      compartment modeling (Other) / dynamic PET/CT (Other) /
                      fractal analysis (Other) / metastatic melanoma (Other) /
                      pharmacokinetics (Other)},
      cin          = {E060 / C060},
      ddc          = {610},
      cid          = {I:(DE-He78)E060-20160331 / I:(DE-He78)C060-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33804417},
      doi          = {10.3390/cancers13051019},
      url          = {https://inrepo02.dkfz.de/record/168300},
}