TY  - JOUR
AU  - Zwicker, Felix
AU  - Hoefel, Sebastian
AU  - Kirchner, Corinna
AU  - Huber, Peter E
AU  - Debus, Juergen
AU  - Schempp, Michael
TI  - Hypofractionated Radiotherapy With Simultaneous-integrated Boost After Breast-conserving Surgery Compared to Standard Boost-applications Using Helical Tomotherapy With TomoEdge.
JO  - Anticancer research
VL  - 41
IS  - 4
SN  - 1791-7530
CY  - Attiki
M1  - DKFZ-2021-00818
SP  - 1909 - 1920
PY  - 2021
N1  - #EA:E055#
AB  - This comparative plan study examines a range of boost-radiation methods in adjuvant radiotherapy of breast cancer using helical intensity-modulated radiotherapy with TomoEdge-technique. Impact of hypofractionated radiation with simultaneous-integrated boost (SIB) and influence of differing assumed α/β-values were examined.For 10 patients with left-sided breast cancer each four helical IMRT-plans with TomoEdge-technique were created: hypofractionated+SIB (H-SIB) (42.4/54.4 Gy, 16 fractions), normofractionated+SIB (N-SIB) (50.4/64.4 Gy, 28 fractions), hypofractionated+sequential-boost (H-SB) (42.4 Gy/16 fractions+16 Gy/8 fractions), normofractionated+ sequential-boost (N-SB) (50.4 Gy/28 fractions+16 Gy/8 fractions). Equivalent doses (EQD2) to organs-at-risk (OAR) and irradiated mammary-gland were analysed for different assumed α/β-values.The mean EQD2 to OAR was significantly lower using hypofractionated radiation-techniques. H-SIB and H-SB were not significantly different. H-SIB and N-SIB conformed significantly better to the breast planning-target volume (PTV) and boost-volume (BV) than H-SB and N-SB. Regarding BV, mean EQD2 was significantly higher for all α/β-values investigated when using H-SIB and N-SIB. Regarding PTV, there were no clinically relevant differences.Relating to dosimetry, H-SIB is effective compared to standard-boost-techniques.
KW  - Hypofractionated radiotherapy (Other)
KW  - IMRT (Other)
KW  - SIB (Other)
KW  - TomoEdge (Other)
KW  - breast cancer (Other)
KW  - helical tomotherapy (Other)
KW  - simultaneous integrated boost (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:33813396
DO  - DOI:10.21873/anticanres.14957
UR  - https://inrepo02.dkfz.de/record/168307
ER  -