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000168321 0247_ $$2ISSN$$a1938-3215
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000168321 037__ $$aDKFZ-2021-00829
000168321 041__ $$aEnglish
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000168321 1001_ $$aClasen, Joanna L$$b0
000168321 245__ $$aA comparison of complementary measures of vitamin B6 status, function, and metabolism in the European Prospective Investigation into Cancer and Nutrition (EPIC) study.
000168321 260__ $$aOxford$$bOxford University Press$$c2021
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000168321 500__ $$a2021 Jul 1;114(1):338-347
000168321 520__ $$aVitamin B6 insufficiency has been linked to increased risk of cancer and other chronic diseases. The circulating concentration of pyridoxal 5'-phosphate (PLP) is a commonly used measure of vitamin B6 status. Ratios of substrates indicating PLP coenzymatic function and metabolism may be useful complementary measures to further explore the role of vitamin B6 in health.We explored the sensitivity of 5 outcomes, namely PLP concentration, homocysteine:cysteine (Hcy:Cys), cystathionine:cysteine (Cysta:Cys), the 3´-hydroxykynurenine ratio (HKr), and the 4-pyridoxic acid ratio (PAr) to vitamin B6 intake as well as personal and lifestyle characteristics.Dietary intake and biomarker data were collected from participants from 3 nested case-control studies within the European Prospective Investigation into Cancer and Nutrition (EPIC). Bayesian regression models assessed the associations of the 5 biomarker outcomes with vitamin B6 intake and personal and lifestyle covariates. Analogous models examined the relations of Hcy:Cys, Cysta:Cys, and HKr with PLP.In total, 4608 participants were included in the analyses. Vitamin B6 intake was most strongly associated with PLP, moderately associated with Hcy:Cys, Cysta:Cys, and HKr, and not associated with PAr (fold change in marker given a doubling of vitamin B6 intake: PLP 1.60 [95% credible interval (CrI): 1.50, 1.71]; Hcy:Cys 0.87 [95% CrI: 0.84, 0.90]; Cysta:Cys 0.89 [95% CrI: 0.84, 0.94]; HKr 0.88 [95% CrI: 0.85, 0.91]; PAr 1.00 [95% CrI: 0.95, 1.05]). PAr was most sensitive to age, and HKr was least sensitive to BMI and alcohol intake. Sex and menopause status were strongly associated with all 5 markers.We found that 5 different markers, capturing different aspects of vitamin B6-related biological processes, varied in their associations with vitamin B6 intake and personal and lifestyle predictors.
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000168321 650_7 $$2Other$$aPLP
000168321 650_7 $$2Other$$adietary biomarkers
000168321 650_7 $$2Other$$akynurenine pathway
000168321 650_7 $$2Other$$atranssulfuration pathway
000168321 650_7 $$2Other$$avitamin B6
000168321 7001_ $$aHeath, Alicia K$$b1
000168321 7001_ $$aVan Puyvelde, Heleen$$b2
000168321 7001_ $$aHuybrechts, Inge$$b3
000168321 7001_ $$aPark, Jin Young$$b4
000168321 7001_ $$aFerrari, Pietro$$b5
000168321 7001_ $$aJohansson, Mattias$$b6
000168321 7001_ $$aScelo, Ghislaine$$b7
000168321 7001_ $$aUlvik, Arve$$b8
000168321 7001_ $$aMidttun, Øivind$$b9
000168321 7001_ $$aUeland, Per Magne$$b10
000168321 7001_ $$aDahm, Christina C$$b11
000168321 7001_ $$aHalkjær, Jytte$$b12
000168321 7001_ $$aOlsen, Anja$$b13
000168321 7001_ $$0P:(DE-He78)79ab945544e5bc017a2317b6146ed3aa$$aJohnson, Theron$$b14$$udkfz
000168321 7001_ $$0P:(DE-He78)fb68a9386399d72d84f7f34cfc6048b4$$aKatzke, Verena$$b15$$udkfz
000168321 7001_ $$aSchulze, Matthias B$$b16
000168321 7001_ $$aMasala, Giovanna$$b17
000168321 7001_ $$aSegrado, Francesco$$b18
000168321 7001_ $$ade Magistris, Maria Santucci$$b19
000168321 7001_ $$aSacerdote, Carlotta$$b20
000168321 7001_ $$aOcké, Marga C$$b21
000168321 7001_ $$aLuján-Barroso, Leila$$b22
000168321 7001_ $$aChing-López, Ana$$b23
000168321 7001_ $$aHuerta, José María$$b24
000168321 7001_ $$aArdanaz, Eva$$b25
000168321 7001_ $$aAmiano, Pilar$$b26
000168321 7001_ $$aEricson, Ulrika$$b27
000168321 7001_ $$aManjer, Jonas$$b28
000168321 7001_ $$aGylling, Björn$$b29
000168321 7001_ $$aJohansson, Ingegerd$$b30
000168321 7001_ $$aSchmidt, Julie$$b31
000168321 7001_ $$aWeiderpass, Elisabete$$b32
000168321 7001_ $$aRiboli, Elio$$b33
000168321 7001_ $$aCross, Amanda J$$b34
000168321 7001_ $$aMuller, David C$$b35
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