TY  - JOUR
AU  - Clasen, Joanna L
AU  - Heath, Alicia K
AU  - Van Puyvelde, Heleen
AU  - Huybrechts, Inge
AU  - Park, Jin Young
AU  - Ferrari, Pietro
AU  - Johansson, Mattias
AU  - Scelo, Ghislaine
AU  - Ulvik, Arve
AU  - Midttun, Øivind
AU  - Ueland, Per Magne
AU  - Dahm, Christina C
AU  - Halkjær, Jytte
AU  - Olsen, Anja
AU  - Johnson, Theron
AU  - Katzke, Verena
AU  - Schulze, Matthias B
AU  - Masala, Giovanna
AU  - Segrado, Francesco
AU  - de Magistris, Maria Santucci
AU  - Sacerdote, Carlotta
AU  - Ocké, Marga C
AU  - Luján-Barroso, Leila
AU  - Ching-López, Ana
AU  - Huerta, José María
AU  - Ardanaz, Eva
AU  - Amiano, Pilar
AU  - Ericson, Ulrika
AU  - Manjer, Jonas
AU  - Gylling, Björn
AU  - Johansson, Ingegerd
AU  - Schmidt, Julie
AU  - Weiderpass, Elisabete
AU  - Riboli, Elio
AU  - Cross, Amanda J
AU  - Muller, David C
TI  - A comparison of complementary measures of vitamin B6 status, function, and metabolism in the European Prospective Investigation into Cancer and Nutrition (EPIC) study.
JO  - The American journal of clinical nutrition
VL  - 114
IS  - 1
SN  - 1938-3207
CY  - Oxford
PB  - Oxford University Press
M1  - DKFZ-2021-00829
SP  - 338-347
PY  - 2021
N1  - 2021 Jul 1;114(1):338-347
AB  - Vitamin B6 insufficiency has been linked to increased risk of cancer and other chronic diseases. The circulating concentration of pyridoxal 5'-phosphate (PLP) is a commonly used measure of vitamin B6 status. Ratios of substrates indicating PLP coenzymatic function and metabolism may be useful complementary measures to further explore the role of vitamin B6 in health.We explored the sensitivity of 5 outcomes, namely PLP concentration, homocysteine:cysteine (Hcy:Cys), cystathionine:cysteine (Cysta:Cys), the 3´-hydroxykynurenine ratio (HKr), and the 4-pyridoxic acid ratio (PAr) to vitamin B6 intake as well as personal and lifestyle characteristics.Dietary intake and biomarker data were collected from participants from 3 nested case-control studies within the European Prospective Investigation into Cancer and Nutrition (EPIC). Bayesian regression models assessed the associations of the 5 biomarker outcomes with vitamin B6 intake and personal and lifestyle covariates. Analogous models examined the relations of Hcy:Cys, Cysta:Cys, and HKr with PLP.In total, 4608 participants were included in the analyses. Vitamin B6 intake was most strongly associated with PLP, moderately associated with Hcy:Cys, Cysta:Cys, and HKr, and not associated with PAr (fold change in marker given a doubling of vitamin B6 intake: PLP 1.60 [95
KW  - PLP (Other)
KW  - dietary biomarkers (Other)
KW  - kynurenine pathway (Other)
KW  - transsulfuration pathway (Other)
KW  - vitamin B6 (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:33829249
DO  - DOI:10.1093/ajcn/nqab045
UR  - https://inrepo02.dkfz.de/record/168321
ER  -