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      author       = {J. L. Clasen and A. K. Heath and H. Van Puyvelde and I.
                      Huybrechts and J. Y. Park and P. Ferrari and M. Johansson
                      and G. Scelo and A. Ulvik and Ø. Midttun and P. M. Ueland
                      and C. C. Dahm and J. Halkjær and A. Olsen and T.
                      Johnson$^*$ and V. Katzke$^*$ and M. B. Schulze and G.
                      Masala and F. Segrado and M. S. de Magistris and C.
                      Sacerdote and M. C. Ocké and L. Luján-Barroso and A.
                      Ching-López and J. M. Huerta and E. Ardanaz and P. Amiano
                      and U. Ericson and J. Manjer and B. Gylling and I. Johansson
                      and J. Schmidt and E. Weiderpass and E. Riboli and A. J.
                      Cross and D. C. Muller},
      title        = {{A} comparison of complementary measures of vitamin {B}6
                      status, function, and metabolism in the {E}uropean
                      {P}rospective {I}nvestigation into {C}ancer and {N}utrition
                      ({EPIC}) study.},
      journal      = {The American journal of clinical nutrition},
      volume       = {114},
      number       = {1},
      issn         = {1938-3207},
      address      = {Oxford},
      publisher    = {Oxford University Press},
      reportid     = {DKFZ-2021-00829},
      pages        = {338-347},
      year         = {2021},
      note         = {2021 Jul 1;114(1):338-347},
      abstract     = {Vitamin B6 insufficiency has been linked to increased risk
                      of cancer and other chronic diseases. The circulating
                      concentration of pyridoxal 5'-phosphate (PLP) is a commonly
                      used measure of vitamin B6 status. Ratios of substrates
                      indicating PLP coenzymatic function and metabolism may be
                      useful complementary measures to further explore the role of
                      vitamin B6 in health.We explored the sensitivity of 5
                      outcomes, namely PLP concentration, homocysteine:cysteine
                      (Hcy:Cys), cystathionine:cysteine (Cysta:Cys), the
                      3´-hydroxykynurenine ratio (HKr), and the 4-pyridoxic acid
                      ratio (PAr) to vitamin B6 intake as well as personal and
                      lifestyle characteristics.Dietary intake and biomarker data
                      were collected from participants from 3 nested case-control
                      studies within the European Prospective Investigation into
                      Cancer and Nutrition (EPIC). Bayesian regression models
                      assessed the associations of the 5 biomarker outcomes with
                      vitamin B6 intake and personal and lifestyle covariates.
                      Analogous models examined the relations of Hcy:Cys,
                      Cysta:Cys, and HKr with PLP.In total, 4608 participants were
                      included in the analyses. Vitamin B6 intake was most
                      strongly associated with PLP, moderately associated with
                      Hcy:Cys, Cysta:Cys, and HKr, and not associated with PAr
                      (fold change in marker given a doubling of vitamin B6
                      intake: PLP 1.60 $[95\%$ credible interval (CrI): 1.50,
                      1.71]; Hcy:Cys 0.87 $[95\%$ CrI: 0.84, 0.90]; Cysta:Cys 0.89
                      $[95\%$ CrI: 0.84, 0.94]; HKr 0.88 $[95\%$ CrI: 0.85, 0.91];
                      PAr 1.00 $[95\%$ CrI: 0.95, 1.05]). PAr was most sensitive
                      to age, and HKr was least sensitive to BMI and alcohol
                      intake. Sex and menopause status were strongly associated
                      with all 5 markers.We found that 5 different markers,
                      capturing different aspects of vitamin B6-related biological
                      processes, varied in their associations with vitamin B6
                      intake and personal and lifestyle predictors.},
      keywords     = {PLP (Other) / dietary biomarkers (Other) / kynurenine
                      pathway (Other) / transsulfuration pathway (Other) / vitamin
                      B6 (Other)},
      cin          = {C020},
      ddc          = {570},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33829249},
      doi          = {10.1093/ajcn/nqab045},
      url          = {https://inrepo02.dkfz.de/record/168321},