guest ::
| Home > Publications database > Development of a method for generating SNP interaction-aware polygenic risk scores for radiotherapy toxicity. > print |
| Home > Publications database > Development of a method for generating SNP interaction-aware polygenic risk scores for radiotherapy toxicity. > print |
| 001 | 168332 | ||
| 005 | 20240229133604.0 | ||
| 024 | 7 | _ | |a 10.1016/j.radonc.2021.03.024 |2 doi |
| 024 | 7 | _ | |a pmid:33838170 |2 pmid |
| 024 | 7 | _ | |a 0167-8140 |2 ISSN |
| 024 | 7 | _ | |a 1879-0887 |2 ISSN |
| 024 | 7 | _ | |a altmetric:103678980 |2 altmetric |
| 037 | _ | _ | |a DKFZ-2021-00835 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Rares Franco, Nicola |b 0 |
| 245 | _ | _ | |a Development of a method for generating SNP interaction-aware polygenic risk scores for radiotherapy toxicity. |
| 260 | _ | _ | |a Amsterdam [u.a.] |c 2021 |b Elsevier Science |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1619619875_10045 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 500 | _ | _ | |a 2021 Apr 8;159:241-248 |
| 520 | _ | _ | |a To identify the effect of single nucleotide polymorphism (SNP) interactions on the risk of toxicity following radiotherapy (RT) for prostate cancer (PCa) and propose a new method for polygenic risk score incorporating SNP-SNP interactions (PRSi).Analysis included the REQUITE PCa cohort that received external beam RT and was followed for 2 years. Late toxicity endpoints were: rectal bleeding, urinary frequency, haematuria, nocturia, decreased urinary stream. Among 43 literature-identified SNPs, the 30% most strongly associated with each toxicity were tested. SNP-SNP combinations (named SNP-allele sets) seen in ≥10% of the cohort were condensed into risk (RS) and protection (PS) scores, respectively indicating increased or decreased toxicity risk. Performance of RS and PS was evaluated by logistic regression. RS and PS were then combined into a single PRSi evaluated by area under the receiver operating characteristic curve (AUC).Among 1,387 analysed patients, toxicity rates were 11.7% (rectal bleeding), 4.0% (urinary frequency), 5.5% (haematuria), 7.8% (nocturia) and 17.1% (decreased urinary stream). RS and PS combined 8 to 15 different SNP-allele sets, depending on the toxicity endpoint. Distributions of PRSi differed significantly in patients with/without toxicity with AUCs ranging from 0.61 to 0.78. PRSi was better than the classical summed PRS, particularly for the urinary frequency, haematuria and decreased urinary stream endpoints.Our method incorporates SNP-SNP interactions when calculating PRS for radiotherapy toxicity. Our approach is better than classical summation in discriminating patients with toxicity and should enable incorporating genetic information to improve normal tissue complication probability models. |
| 536 | _ | _ | |a 313 - Krebsrisikofaktoren und Prävention (POF4-313) |0 G:(DE-HGF)POF4-313 |c POF4-313 |x 0 |f POF IV |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, , Journals: inrepo01.inet.dkfz-heidelberg.de |
| 650 | _ | 7 | |a SNPs |2 Other |
| 650 | _ | 7 | |a epistasis |2 Other |
| 650 | _ | 7 | |a genetic risk factors |2 Other |
| 650 | _ | 7 | |a late toxicity |2 Other |
| 650 | _ | 7 | |a prostate cancer |2 Other |
| 650 | _ | 7 | |a radiotherapy |2 Other |
| 700 | 1 | _ | |a Carlotta Massi, Michela |b 1 |
| 700 | 1 | _ | |a Ieva, Francesca |b 2 |
| 700 | 1 | _ | |a Manzoni, Andrea |b 3 |
| 700 | 1 | _ | |a Maria Paganoni, Anna |b 4 |
| 700 | 1 | _ | |a Zunino, Paolo |b 5 |
| 700 | 1 | _ | |a Veldeman, Liv |b 6 |
| 700 | 1 | _ | |a Ost, Piet |b 7 |
| 700 | 1 | _ | |a Fonteyne, Valérie |b 8 |
| 700 | 1 | _ | |a Talbot, Christopher J |b 9 |
| 700 | 1 | _ | |a Rattay, Tim |b 10 |
| 700 | 1 | _ | |a Webb, Adam |b 11 |
| 700 | 1 | _ | |a Johnson, Kerstie |b 12 |
| 700 | 1 | _ | |a Lambrecht, Maarten |b 13 |
| 700 | 1 | _ | |a Haustermans, Karin |b 14 |
| 700 | 1 | _ | |a De Meerleer, Gert |b 15 |
| 700 | 1 | _ | |a de Ruysscher, Dirk |b 16 |
| 700 | 1 | _ | |a Vanneste, Ben |b 17 |
| 700 | 1 | _ | |a Van Limbergen, Evert |b 18 |
| 700 | 1 | _ | |a Choudhury, Ananya |b 19 |
| 700 | 1 | _ | |a Elliott, Rebecca M |b 20 |
| 700 | 1 | _ | |a Sperk, Elena |b 21 |
| 700 | 1 | _ | |a Veldwijk, Marlon |b 22 |
| 700 | 1 | _ | |a Herskind, Carsten |b 23 |
| 700 | 1 | _ | |a Avuzzi, Barbara |b 24 |
| 700 | 1 | _ | |a Noris Chiorda, Barbara |b 25 |
| 700 | 1 | _ | |a Valdagni, Riccardo |b 26 |
| 700 | 1 | _ | |a Azria, David |b 27 |
| 700 | 1 | _ | |a Farcy-Jacquet, Marie-Pierre |b 28 |
| 700 | 1 | _ | |a Brengues, Muriel |b 29 |
| 700 | 1 | _ | |a Rosenstein, Barry S |b 30 |
| 700 | 1 | _ | |a Stock, Richard G |b 31 |
| 700 | 1 | _ | |a Vega, Ana |b 32 |
| 700 | 1 | _ | |a Elías Aguado-Barrera, Miguel |b 33 |
| 700 | 1 | _ | |a Sosa-Fajardo, Paloma |b 34 |
| 700 | 1 | _ | |a Dunning, Alison M |b 35 |
| 700 | 1 | _ | |a Fachal, Laura |b 36 |
| 700 | 1 | _ | |a Kerns, Sarah L |b 37 |
| 700 | 1 | _ | |a Payne, Debbie |b 38 |
| 700 | 1 | _ | |a Chang-Claude, Jenny |0 P:(DE-He78)c259d6cc99edf5c7bc7ce22c7f87c253 |b 39 |u dkfz |
| 700 | 1 | _ | |a Seibold, Petra |0 P:(DE-He78)fd17a8dbf8d08ea5bb656dfef7398215 |b 40 |u dkfz |
| 700 | 1 | _ | |a Ml West, Catharine |b 41 |
| 700 | 1 | _ | |a Rancati, Tiziana |b 42 |
| 700 | 1 | _ | |a Consortium, REQUITE |b 43 |e Collaboration Author |
| 700 | 1 | _ | |a Lievens, Yolande |b 44 |
| 700 | 1 | _ | |a van Eijkeren, Marc |b 45 |
| 700 | 1 | _ | |a Monten, Christel |b 46 |
| 700 | 1 | _ | |a De Neve, Wilfried |b 47 |
| 700 | 1 | _ | |a Peeters, Stephanie |b 48 |
| 700 | 1 | _ | |a Weltens, Caroline |b 49 |
| 700 | 1 | _ | |a Defraene, Gilles |b 50 |
| 700 | 1 | _ | |a van Limberghen, Erik |b 51 |
| 700 | 1 | _ | |a Briers, Erik |b 52 |
| 700 | 1 | _ | |a Bourgier, Celine |b 53 |
| 700 | 1 | _ | |a Draghici, Roxana |b 54 |
| 700 | 1 | _ | |a Bons, Francoise |b 55 |
| 700 | 1 | _ | |a Blaschke, Thomas |b 56 |
| 700 | 1 | _ | |a Weiß, Christian |b 57 |
| 700 | 1 | _ | |a Helmbold, Irmgard |b 58 |
| 700 | 1 | _ | |a Weißenberger, Christian |b 59 |
| 700 | 1 | _ | |a Stegmaier, Petra |b 60 |
| 700 | 1 | _ | |a Claßen, Johannes |b 61 |
| 700 | 1 | _ | |a Giesche, Ulrich |b 62 |
| 700 | 1 | _ | |a Sautter-Bihl, Marie-Luise |b 63 |
| 700 | 1 | _ | |a Neu, Burkhard |b 64 |
| 700 | 1 | _ | |a Schnabel, Thomas |b 65 |
| 700 | 1 | _ | |a Ehmann, Michael |b 66 |
| 700 | 1 | _ | |a Gauter-Fleckenstein, Benjamin |b 67 |
| 700 | 1 | _ | |a Schäfer, Jörg |b 68 |
| 700 | 1 | _ | |a Giandini, Tommaso |b 69 |
| 700 | 1 | _ | |a Franceschini, Marzia |b 70 |
| 700 | 1 | _ | |a Sangalli, Claudia |b 71 |
| 700 | 1 | _ | |a Morlino, Sara |b 72 |
| 700 | 1 | _ | |a Lozza, Laura |b 73 |
| 700 | 1 | _ | |a De Santis, Maria C |b 74 |
| 700 | 1 | _ | |a Pietro, Gabriele |b 75 |
| 700 | 1 | _ | |a Delmastro, Elena |b 76 |
| 700 | 1 | _ | |a Garibaldi, Elisabetta |b 77 |
| 700 | 1 | _ | |a Cicchetti, Alessandro |b 78 |
| 700 | 1 | _ | |a Piqué-Leiva, Bibiana |b 79 |
| 700 | 1 | _ | |a Molla, Meritxel |b 80 |
| 700 | 1 | _ | |a Giraldo, Alexandra |b 81 |
| 700 | 1 | _ | |a Ramos, Monica |b 82 |
| 700 | 1 | _ | |a Lobato-Busto, Ramon |b 83 |
| 700 | 1 | _ | |a Torrado Moya, Laura |b 84 |
| 700 | 1 | _ | |a Dominguez-Rios, Isabel |b 85 |
| 700 | 1 | _ | |a Fajardo-Paneque, Irene |b 86 |
| 700 | 1 | _ | |a Calvo-Crespo, Patricia |b 87 |
| 700 | 1 | _ | |a Carballo, Ana |b 88 |
| 700 | 1 | _ | |a Peleteiro, Paula |b 89 |
| 700 | 1 | _ | |a Olivia-Fuentes-Rios |b 90 |
| 700 | 1 | _ | |a Gomez-Caamano, Antonio |b 91 |
| 700 | 1 | _ | |a Harrop, Victoria |b 92 |
| 700 | 1 | _ | |a Payne, Debbie |b 93 |
| 700 | 1 | _ | |a Keni, Manjusha |b 94 |
| 700 | 1 | _ | |a Symonds, Paul R |b 95 |
| 700 | 1 | _ | |a Lavers, Samuel |b 96 |
| 700 | 1 | _ | |a Wright, Simon |b 97 |
| 700 | 1 | _ | |a Thiagarajan, Sridhar |b 98 |
| 700 | 1 | _ | |a Aznar-Garcia, Luis |b 99 |
| 700 | 1 | _ | |a Kancherla, Kiran |b 100 |
| 700 | 1 | _ | |a Kent, Christopher |b 101 |
| 700 | 1 | _ | |a Vasanthan, Subramaniam |b 102 |
| 700 | 1 | _ | |a Appleton, Donna |b 103 |
| 700 | 1 | _ | |a Kaushik, Monika |b 104 |
| 700 | 1 | _ | |a Kenny, Frances |b 105 |
| 700 | 1 | _ | |a Khout, Hazem |b 106 |
| 700 | 1 | _ | |a Krupa, Jaroslaw |b 107 |
| 700 | 1 | _ | |a Lambert, Kelly V |b 108 |
| 700 | 1 | _ | |a Pilgrim, Simon |b 109 |
| 700 | 1 | _ | |a Shokuhi, Sheila |b 110 |
| 700 | 1 | _ | |a Valassiadou, Kalliope |b 111 |
| 700 | 1 | _ | |a Bioangiu, Ion |b 112 |
| 700 | 1 | _ | |a Sampson, Kufre |b 113 |
| 700 | 1 | _ | |a Osman, Ahmed |b 114 |
| 700 | 1 | _ | |a Faivre-Finn, Corinne |b 115 |
| 700 | 1 | _ | |a Foweraker, Karen |b 116 |
| 700 | 1 | _ | |a Pascoe, Abigail |b 117 |
| 700 | 1 | _ | |a Esler, Claire P |b 118 |
| 700 | 1 | _ | |a Ward, Tim |b 119 |
| 700 | 1 | _ | |a Higginson, Daniel S |b 120 |
| 700 | 1 | _ | |a Green, Sheryl |b 121 |
| 773 | _ | _ | |a 10.1016/j.radonc.2021.03.024 |g p. S0167814021061612 |0 PERI:(DE-600)1500707-8 |p 241-248 |t Radiotherapy and oncology |v 159 |y 2021 |x 0167-8140 |
| 909 | C | O | |o oai:inrepo02.dkfz.de:168332 |p VDB |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 39 |6 P:(DE-He78)c259d6cc99edf5c7bc7ce22c7f87c253 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 40 |6 P:(DE-He78)fd17a8dbf8d08ea5bb656dfef7398215 |
| 913 | 0 | _ | |a DE-HGF |b Gesundheit |l Krebsforschung |1 G:(DE-HGF)POF3-310 |0 G:(DE-HGF)POF3-313 |3 G:(DE-HGF)POF3 |2 G:(DE-HGF)POF3-300 |4 G:(DE-HGF)POF |v Cancer risk factors and prevention |x 0 |
| 913 | 1 | _ | |a DE-HGF |b Gesundheit |l Krebsforschung |1 G:(DE-HGF)POF4-310 |0 G:(DE-HGF)POF4-313 |3 G:(DE-HGF)POF4 |2 G:(DE-HGF)POF4-300 |4 G:(DE-HGF)POF |v Krebsrisikofaktoren und Prävention |x 0 |
| 914 | 1 | _ | |y 2021 |
| 915 | _ | _ | |a Nationallizenz |0 StatID:(DE-HGF)0420 |2 StatID |d 2021-01-31 |w ger |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |d 2021-01-31 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |d 2021-01-31 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Clarivate Analytics Master Journal List |d 2021-01-31 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0160 |2 StatID |b Essential Science Indicators |d 2021-01-31 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1050 |2 StatID |b BIOSIS Previews |d 2021-01-31 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1110 |2 StatID |b Current Contents - Clinical Medicine |d 2021-01-31 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1190 |2 StatID |b Biological Abstracts |d 2021-01-31 |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0113 |2 StatID |b Science Citation Index Expanded |d 2021-01-31 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |d 2021-01-31 |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b RADIOTHER ONCOL : 2019 |d 2021-01-31 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0600 |2 StatID |b Ebsco Academic Search |d 2021-01-31 |
| 915 | _ | _ | |a Peer Review |0 StatID:(DE-HGF)0030 |2 StatID |b ASC |d 2021-01-31 |
| 915 | _ | _ | |a IF < 5 |0 StatID:(DE-HGF)9900 |2 StatID |d 2021-01-31 |
| 920 | 1 | _ | |0 I:(DE-He78)C020-20160331 |k C020 |l C020 Epidemiologie von Krebs |x 0 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a I:(DE-He78)C020-20160331 |
| 980 | _ | _ | |a UNRESTRICTED |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|