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@ARTICLE{Matta:168394,
      author       = {M. Matta and I. Huybrechts and C. Biessy and C. Casagrande
                      and S. Yammine and A. Fournier and K. S. Olsen and M. Lukic
                      and I. T. Gram and E. Ardanaz and M.-J. Sánchez and L.
                      Dossus and R. T. Fortner$^*$ and B. Srour$^*$ and F.
                      Jannasch and M. B. Schulze and P. Amiano and A. Agudo and S.
                      Colorado-Yohar and J. R. Quirós and R. Tumino and S. Panico
                      and G. Masala and V. Pala and C. Sacerdote and A.
                      Tjønneland and A. Olsen and C. C. Dahm and A. H. Rosendahl
                      and S. Borgquist and M. Wennberg and A. K. Heath and D. Aune
                      and J. Schmidt and E. Weiderpass and V. Chajes and M. J.
                      Gunter and N. Murphy},
      title        = {{D}ietary intake of trans fatty acids and breast cancer
                      risk in 9 {E}uropean countries.},
      journal      = {BMC medicine},
      volume       = {19},
      number       = {1},
      issn         = {1741-7015},
      address      = {Heidelberg [u.a.]},
      publisher    = {Springer},
      reportid     = {DKFZ-2021-00881},
      pages        = {81},
      year         = {2021},
      abstract     = {Trans fatty acids (TFAs) have been hypothesised to
                      influence breast cancer risk. However, relatively few
                      prospective studies have examined this relationship, and
                      well-powered analyses according to hormone receptor-defined
                      molecular subtypes, menopausal status, and body size have
                      rarely been conducted.In the European Prospective
                      Investigation into Cancer and Nutrition (EPIC), we
                      investigated the associations between dietary intakes of
                      TFAs (industrial trans fatty acids [ITFAs] and ruminant
                      trans fatty acids [RTFAs]) and breast cancer risk among
                      318,607 women. Multivariable hazard ratios (HRs) and $95\%$
                      confidence intervals (CIs) were estimated using Cox
                      proportional hazards models, adjusted for other breast
                      cancer risk factors.After a median follow-up of 8.1 years,
                      13,241 breast cancer cases occurred. In the
                      multivariable-adjusted model, higher total ITFA intake was
                      associated with elevated breast cancer risk (HR for highest
                      vs lowest quintile, 1.14, $95\%$ CI 1.06-1.23; P trend =
                      0.001). A similar positive association was found between
                      intake of elaidic acid, the predominant ITFA, and breast
                      cancer risk (HR for highest vs lowest quintile, 1.14, $95\%$
                      CI 1.06-1.23; P trend = 0.001). Intake of total RTFAs was
                      also associated with higher breast cancer risk (HR for
                      highest vs lowest quintile, 1.09, $95\%$ CI 1.01-1.17; P
                      trend = 0.015). For individual RTFAs, we found positive
                      associations with breast cancer risk for dietary intakes of
                      two strongly correlated fatty acids (Spearman correlation r
                      = 0.77), conjugated linoleic acid (HR for highest vs lowest
                      quintile, 1.11, $95\%$ CI 1.03-1.20; P trend = 0.001) and
                      palmitelaidic acid (HR for highest vs lowest quintile, 1.08,
                      $95\%$ CI 1.01-1.16; P trend = 0.028). Similar associations
                      were found for total ITFAs and RTFAs with breast cancer risk
                      according to menopausal status, body mass index, and breast
                      cancer subtypes.These results support the hypothesis that
                      higher dietary intakes of ITFAs, in particular elaidic acid,
                      are associated with elevated breast cancer risk. Due to the
                      high correlation between conjugated linoleic acid and
                      palmitelaidic acid, we were unable to disentangle the
                      positive associations found for these fatty acids with
                      breast cancer risk. Further mechanistic studies are needed
                      to identify biological pathways that may underlie these
                      associations.},
      keywords     = {Breast cancer (Other) / Diet (Other) / Industrial trans
                      fatty acids (Other) / Ruminant trans fatty acids (Other)},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33781249},
      pmc          = {pmc:PMC8008592},
      doi          = {10.1186/s12916-021-01952-3},
      url          = {https://inrepo02.dkfz.de/record/168394},
}