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@ARTICLE{Butt:168440,
      author       = {J. A. Butt$^*$ and M. Jenab and J. Werner and V. Fedirko
                      and E. Weiderpass and C. C. Dahm and A. Tjønneland and A.
                      Olsen and M.-C. Boutron-Ruault and J. A. Rothwell and G.
                      Severi and R. Kaaks$^*$ and R. Turzanski-Fortner$^*$ and K.
                      Aleksandrova and M. Schulze and D. Palli and V. Pala and S.
                      Panico and R. Tumino and C. Sacerdote and B.
                      Bueno-de-Mesquita and C. H. Van Gils and I. T. Gram and M.
                      Lukic and N. Sala and M. J. Sánchez Pérez and E. Ardanaz
                      and M.-D. Chirlaque and R. Palmquist and T. Löwenmark and
                      R. C. Travis and A. Heath and A. J. Cross and H. Freisling
                      and S. Zouiouich and E. Aglago and T. Waterboer$^*$ and D.
                      J. Hughes},
      title        = {{A}ssociation of {P}re-diagnostic {A}ntibody {R}esponses to
                      {E}scherichia coli and {B}acteroides fragilis {T}oxin
                      {P}roteins with {C}olorectal {C}ancer in a {E}uropean
                      {C}ohort.},
      journal      = {Gut microbes},
      volume       = {13},
      number       = {1},
      issn         = {1949-0984},
      address      = {Austin, Tex.},
      publisher    = {Landes Bioscience},
      reportid     = {DKFZ-2021-00914},
      pages        = {1903825},
      year         = {2021},
      note         = {#EA:F022# /Jan-Dec 2021;13(1):1-14 / 1903825},
      abstract     = {Experimental evidence has implicated genotoxic Escherichia
                      coli (E. coli) and enterotoxigenic Bacteroides fragilis
                      (ETBF) in the development of colorectal cancer (CRC).
                      However, evidence from epidemiological studies is sparse. We
                      therefore assessed the association of serological markers of
                      E. coli and ETBF exposure with odds of developing CRC in the
                      European Prospective Investigation into Nutrition and Cancer
                      (EPIC) study.Serum samples of incident CRC cases and matched
                      controls (n = 442 pairs) were analyzed for immunoglobulin
                      (Ig) A and G antibody responses to seven E. coli proteins
                      and two isoforms of the ETBF toxin via multiplex serology.
                      Multivariable-adjusted conditional logistic regression
                      analyses were used to estimate odds ratios (ORs) and $95\%$
                      confidence intervals (CIs) for the association of
                      sero-positivity to E. coli and ETBF with CRC.The
                      IgA-positivity of any of the tested E. coli antigens was
                      associated with higher odds of developing CRC (OR: 1.42;
                      $95\%$ CI: 1.05-1.91). Dual-positivity for both IgA and IgG
                      to E. coli and ETBF was associated with >1.7-fold higher
                      odds of developing CRC, with a significant association only
                      for IgG (OR: 1.75; $95\%$ CI: 1.04, 2.94). This association
                      was more pronounced when restricted to the proximal colon
                      cancers (OR: 2.62; $95\%$ CI: 1.09, 6.29) compared to those
                      of the distal colon (OR: 1.24; $95\%$ CI: 0.51, 3.00)
                      (pheterogeneity = 0.095). Sero-positivity to E. coli and
                      ETBF was associated with CRC development, suggesting that
                      co-infection of these bacterial species may contribute to
                      colorectal carcinogenesis. These findings warrant further
                      exploration in larger prospective studies and within
                      different population groups.},
      keywords     = {Colorectal cancer (Other) / Escherichia coli (Other) /
                      bacteroides fragilis (Other) / prospective (Other) /
                      serology (Other)},
      cin          = {F022 / F020 / C020},
      ddc          = {570},
      cid          = {I:(DE-He78)F022-20160331 / I:(DE-He78)F020-20160331 /
                      I:(DE-He78)C020-20160331},
      pnm          = {316 - Infektionen, Entzündung und Krebs (POF4-316)},
      pid          = {G:(DE-HGF)POF4-316},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33874856},
      doi          = {10.1080/19490976.2021.1903825},
      url          = {https://inrepo02.dkfz.de/record/168440},
}