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@ARTICLE{Zheng:168443,
      author       = {T. Zheng$^*$ and D. R. Ghasemi$^*$ and K. Okonechnikov$^*$
                      and A. Korshunov$^*$ and M. Sill$^*$ and K. K. Maass$^*$ and
                      P. Benites Goncalves da Silva$^*$ and M. Ryzhova$^*$ and J.
                      Gojo$^*$ and D. Stichel$^*$ and A. Arabzade and R. Kupp and
                      J. Benzel$^*$ and S. Taya and T. Adachi and R. Shiraishi and
                      N. U. Gerber and D. Sturm$^*$ and J. Ecker$^*$ and P.
                      Sievers$^*$ and F. Selt and R. Chapman and C. Haberler and
                      D. Figarella-Branger and G. Reifenberger$^*$ and G.
                      Fleischhack and S. Rutkowski and A. M. Donson and V.
                      Ramaswamy and D. Capper$^*$ and D. W. Ellison and C. C.
                      Herold-Mende and U. Schuller and S. Brandner and P. Hernaiz
                      Driever and J. M. Kros and M. Snuderl and T. Milde$^*$ and
                      R. G. Grundy and M. Hoshino and S. C. Mack and R. J.
                      Gilbertson and D. T. W. Jones$^*$ and M. Kool$^*$ and A. von
                      Deimling$^*$ and S. M. Pfister$^*$ and F. Sahm$^*$ and D.
                      Kawauchi$^*$ and K. Pajtler$^*$},
      title        = {{C}ross-species genomics reveals oncogenic dependencies in
                      {ZFTA}/{C}11orf95 fusion-positive supratentorial
                      ependymomas.},
      journal      = {Cancer discovery},
      volume       = {11},
      number       = {9},
      issn         = {2159-8290},
      address      = {Philadelphia, Pa.},
      reportid     = {DKFZ-2021-00917},
      pages        = {2230-2247},
      year         = {2021},
      note         = {#EA:B062#LA:B062#B300# /2021 Sep;11(9):2230-2247},
      abstract     = {Molecular groups of supratentorial ependymomas comprise
                      tumors with ZFTA-RELA or YAP1-involving fusions and
                      fusion-negative subependymoma. However, occasionally
                      supratentorial ependymomas cannot be readily assigned to any
                      of these groups due to lack of detection of a typical fusion
                      and/or ambiguous DNA methylation-based classification. An
                      unbiased approach with a cohort of unprecedented size
                      revealed distinct methylation clusters composed of tumors
                      with ependymal but also various other histological features
                      containing alternative translocations that shared ZFTA as a
                      partner gene. Somatic overexpression of ZFTA-associated
                      fusion genes in the developing cerebral cortex is capable of
                      inducing tumor formation in vivo, and cross-species
                      comparative analyses identified GLI2 as a key downstream
                      regulator of tumorigenesis in all tumors. Targeting GLI2
                      with arsenic trioxide caused extended survival of
                      tumor-bearing animals, indicating a potential therapeutic
                      vulnerability in ZFTA fusion-positive tumors.},
      cin          = {B062 / HD01 / B300 / B360 / B310 / ED01 / BE01},
      ddc          = {610},
      cid          = {I:(DE-He78)B062-20160331 / I:(DE-He78)HD01-20160331 /
                      I:(DE-He78)B300-20160331 / I:(DE-He78)B360-20160331 /
                      I:(DE-He78)B310-20160331 / I:(DE-He78)ED01-20160331 /
                      I:(DE-He78)BE01-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33879448},
      doi          = {10.1158/2159-8290.CD-20-0963},
      url          = {https://inrepo02.dkfz.de/record/168443},
}