TY  - JOUR
AU  - Papadimitriou, Nikos
AU  - Bouras, Emmanouil
AU  - van den Brandt, Piet A
AU  - Muller, David C
AU  - Papadopoulou, Areti
AU  - Heath, Alicia K
AU  - Critselis, Elena
AU  - Gunter, Marc J
AU  - Vineis, Paolo
AU  - Ferrari, Pietro
AU  - Weiderpass, Elisabete
AU  - Boeing, Heiner
AU  - Bastide, Nadia
AU  - Merritt, Melissa A
AU  - Lopez, David S
AU  - Bergmann, Manuela M
AU  - Perez-Cornago, Aurora
AU  - Schulze, Matthias
AU  - Skeie, Guri
AU  - Srour, Bernard
AU  - Eriksen, Anne Kirstine
AU  - Boden, Stina
AU  - Johansson, Ingegerd
AU  - Nøst, Therese Haugdahl
AU  - Lukic, Marco
AU  - Ricceri, Fulvio
AU  - Ericson, Ulrika
AU  - Huerta, José María
AU  - Dahm, Christina C
AU  - Agnoli, Claudia
AU  - Amiano, Pilar Exezarreta
AU  - Tjønneland, Anne
AU  - Gurrea, Aurelio Barricarte
AU  - Bueno-de-Mesquita, Bas
AU  - Ardanaz, Eva
AU  - Berntsson, Jonna
AU  - Sánchez, Maria-Jose
AU  - Tumino, Rosario
AU  - Panico, Salvatore
AU  - Katzke, Verena
AU  - Jakszyn, Paula
AU  - Masala, Giovanna
AU  - Derksen, Jeroen W G
AU  - Quirós, J Ramón
AU  - Severi, Gianluca
AU  - Cross, Amanda J
AU  - Riboli, Ellio
AU  - Tzoulaki, Ioanna
AU  - Tsilidis, Konstantinos K
TI  - A prospective diet-wide association study for risk of colorectal cancer in EPIC.
JO  - Clinical gastroenterology and hepatology
VL  - 20
IS  - 4
SN  - 1542-3565
CY  - New York, NY
PB  - Elsevier Science
M1  - DKFZ-2021-00956
SP  -  864-873.e13
PY  - 2022
N1  - Volume 20, Issue 4, April 2022, Pages 864-873.e13
AB  - Evidence regarding the association of dietary exposures with colorectal cancer (CRC) risk is not consistent with a few exceptions. Therefore, we conducted a diet-wide association study (DWAS) in the European Prospective Investigation into Cancer and Nutrition (EPIC) to evaluate the associations between several dietary exposures with CRC risk.The association of 92 food and nutrient intakes with CRC risk was assessed in 386,792 participants, 5,069 of whom developed incident CRC. Correction for multiple comparisons was performed using the false discovery rate, and emerging associations were examined in the Netherlands Cohort Study (NLCS). Multiplicative gene-nutrient interactions were also tested in EPIC based on known CRC-associated loci.In EPIC, alcohol, liquor/spirits, wine, beer/cider, soft drinks, and pork were positively associated with CRC, whereas milk, cheese, calcium, phosphorus, magnesium, potassium, riboflavin, vitamin B6, beta-carotene, fruit, fibre, non-white bread, banana, and total protein intakes were inversely associated. Of these 20 associations, 13 were replicated in NLCS, for which a meta-analysis was performed, namely alcohol (summary HR per 1 SD increment in intake: 1.07; 95
KW  - cohort study (Other)
KW  - colorectal cancer (Other)
KW  - epidemiology (Other)
KW  - nutrition (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:33901663
DO  - DOI:10.1016/j.cgh.2021.04.028
UR  - https://inrepo02.dkfz.de/record/168524
ER  -