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@ARTICLE{Papadimitriou:168524,
      author       = {N. Papadimitriou and E. Bouras and P. A. van den Brandt and
                      D. C. Muller and A. Papadopoulou and A. K. Heath and E.
                      Critselis and M. J. Gunter and P. Vineis and P. Ferrari and
                      E. Weiderpass and H. Boeing and N. Bastide and M. A. Merritt
                      and D. S. Lopez and M. M. Bergmann and A. Perez-Cornago and
                      M. Schulze and G. Skeie and B. Srour$^*$ and A. K. Eriksen
                      and S. Boden and I. Johansson and T. H. Nøst and M. Lukic
                      and F. Ricceri and U. Ericson and J. M. Huerta and C. C.
                      Dahm and C. Agnoli and P. E. Amiano and A. Tjønneland and
                      A. B. Gurrea and B. Bueno-de-Mesquita and E. Ardanaz and J.
                      Berntsson and M.-J. Sánchez and R. Tumino and S. Panico and
                      V. Katzke$^*$ and P. Jakszyn and G. Masala and J. W. G.
                      Derksen and J. R. Quirós and G. Severi and A. J. Cross and
                      E. Riboli and I. Tzoulaki and K. K. Tsilidis},
      title        = {{A} prospective diet-wide association study for risk of
                      colorectal cancer in {EPIC}.},
      journal      = {Clinical gastroenterology and hepatology},
      volume       = {20},
      number       = {4},
      issn         = {1542-3565},
      address      = {New York, NY},
      publisher    = {Elsevier Science},
      reportid     = {DKFZ-2021-00956},
      pages        = {864-873.e13},
      year         = {2022},
      note         = {Volume 20, Issue 4, April 2022, Pages 864-873.e13},
      abstract     = {Evidence regarding the association of dietary exposures
                      with colorectal cancer (CRC) risk is not consistent with a
                      few exceptions. Therefore, we conducted a diet-wide
                      association study (DWAS) in the European Prospective
                      Investigation into Cancer and Nutrition (EPIC) to evaluate
                      the associations between several dietary exposures with CRC
                      risk.The association of 92 food and nutrient intakes with
                      CRC risk was assessed in 386,792 participants, 5,069 of whom
                      developed incident CRC. Correction for multiple comparisons
                      was performed using the false discovery rate, and emerging
                      associations were examined in the Netherlands Cohort Study
                      (NLCS). Multiplicative gene-nutrient interactions were also
                      tested in EPIC based on known CRC-associated loci.In EPIC,
                      alcohol, liquor/spirits, wine, beer/cider, soft drinks, and
                      pork were positively associated with CRC, whereas milk,
                      cheese, calcium, phosphorus, magnesium, potassium,
                      riboflavin, vitamin B6, beta-carotene, fruit, fibre,
                      non-white bread, banana, and total protein intakes were
                      inversely associated. Of these 20 associations, 13 were
                      replicated in NLCS, for which a meta-analysis was performed,
                      namely alcohol (summary HR per 1 SD increment in intake:
                      1.07; $95\%CI:1.04-1.09),$ liquor/spirits (1.04; 1.02-1.06),
                      wine (1.04;1.02-1.07), beer/cider (1.06;1.04-1.08), milk
                      (0.95;0.93-0.98), cheese (0.96;0.94-0.99), calcium
                      (0.93;0.90-0.95), phosphorus (0.92;0.90-0.95), magnesium
                      (0.95;0.92-0.98), potassium (0.96;0.94-0.99), riboflavin
                      (0.94;0.92-0.97), beta-carotene (0.96;0.93-0.98), and total
                      protein (0.94;0.92-0.97). None of the gene-nutrient
                      interactions were significant after adjustment for multiple
                      comparisons.Our findings confirm a positive association for
                      alcohol and an inverse association for dairy products and
                      calcium with CRC risk, and also suggest a lower risk at
                      higher dietary intakes of phosphorus, magnesium, potassium,
                      riboflavin, beta-carotene and total protein.},
      keywords     = {cohort study (Other) / colorectal cancer (Other) /
                      epidemiology (Other) / nutrition (Other)},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33901663},
      doi          = {10.1016/j.cgh.2021.04.028},
      url          = {https://inrepo02.dkfz.de/record/168524},
}