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@ARTICLE{Mokry:168526,
      author       = {T. Mokry and J. Pantke and A. Mlynarska-Bujny$^*$ and F. C.
                      Hasse and T. A. Kuder$^*$ and H.-P. Schlemmer$^*$ and H.-U.
                      Kauczor and J. Rom and S. Bickelhaupt$^*$},
      title        = {{D}iffusivity mapping of the ovaries: {V}ariability of
                      apparent diffusion and kurtosis variables over the menstrual
                      cycle and influence of oral contraceptives.},
      journal      = {Magnetic resonance imaging},
      volume       = {80},
      issn         = {0730-725X},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DKFZ-2021-00958},
      pages        = {50-57},
      year         = {2021},
      note         = {#LA:E010# /2021 Jul;80:50-57},
      abstract     = {We aimed to investigate whether quantitative diffusivity
                      variables of healthy ovaries vary during the menstrual cycle
                      and to evaluate alterations in women using oral
                      contraceptives (OC).This prospective study (S-339/2016)
                      included 30 healthy female volunteers, with (n = 15) and
                      without (n = 15) intake of OC between 07/2017 and 09/2019.
                      Participants underwent 3T diffusion-weighted MRI (b-values
                      0-2000 s/mm2) three times during a menstrual cycle (T1 = day
                      1-5; T2 = day 7-12; T3 = day 19-24). Both ovaries were
                      manually three-dimensionally segmented on b = 1500 s/mm2;
                      apparent diffusion coefficient (ADC) calculation and
                      kurtosis fitting (Dapp, Kapp) were performed. Differences in
                      ADC, Dapp and Kapp between time points and groups were
                      compared using repeated measures ANOVA and t-test after
                      Shapiro-Wilk and Brown-Forsythe test for normality and equal
                      variance.In women with a natural menstrual cycle, ADC and
                      kurtosis variables showed significant changes in ovaries
                      with the dominant follicle between T1 vs T2 and T1 vs T3,
                      whilst no differences were observed between T2 vs T3: ADC ±
                      SD for T1 1.524 ± 0.160, T2 1.737 ± 0.160, and T3 1.747 ±
                      0.241 μm2/ms (p = 0.01 T2 vs T1; p = 1.0 T2 vs T3, p =
                      0.003 T3 vs T1); Dapp ± SD for T1 2.018 ± 0.140, T2 2.272
                      ± 0.189, and T3 2.230 ± 0.256 μm2/ms (p = 0.003 T2 vs T1,
                      p = 1.0 T2 vs T3, p = 0.02 T3 vs T1); Kapp ± SD for T1
                      0.614 ± 0.0339, T2 0.546 ± 0.0637, and T3 0.529 ± 0.0567
                      (p < 0.001 T2 vs T1, p = 0.86 T2 vs T3, p < 0.001 T3 vs T1).
                      No significant differences were found in the contralateral
                      ovaries or in females taking OC.Physiological
                      cycle-dependent changes in quantitative diffusivity
                      variables of ovaries should be considered especially when
                      interpreting radiomics analyses in reproductive women.},
      keywords     = {Cyclic changes (Other) / Diffusion kurtosis imaging (Other)
                      / Diffusion-weighted imaging (Other) / Menstrual cycle
                      (Other) / Oral contraceptives (Other) / Ovary (Other)},
      cin          = {E010 / E020},
      ddc          = {610},
      cid          = {I:(DE-He78)E010-20160331 / I:(DE-He78)E020-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33905830},
      doi          = {10.1016/j.mri.2021.04.006},
      url          = {https://inrepo02.dkfz.de/record/168526},
}