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000168554 1001_ $$00000-0002-0442-3284$$aAglago, Elom K$$b0
000168554 245__ $$aDietary intake and plasma phospholipid concentrations of saturated, monounsaturated and trans fatty acids and colorectal cancer risk in the EPIC cohort.
000168554 260__ $$aBognor Regis$$bWiley-Liss$$c2021
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000168554 500__ $$aVolume149, Issue 4 15 August 2021 Pages 865-882
000168554 520__ $$aEpidemiologic studies examining the association between specific fatty acids and colorectal cancer (CRC) risk are inconclusive. We investigated the association between dietary estimates and plasma levels of individual and total saturated (SFA), monounsaturated (MUFA), industrial-processed trans (iTFA), and ruminant-sourced trans (rTFA) fatty acids, and CRC risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). Baseline fatty acid intakes were estimated in 450,112 participants (6,162 developed CRC, median follow-up=15 years). In a nested case-control study, plasma phospholipid fatty acids were determined by gas chromatography in 433 colon cancer cases and 433 matched controls. Multivariable-adjusted hazard ratios (HRs) and odds ratios (ORs) with 95% confidence intervals (CIs) were computed using Cox and conditional logistic regression, respectively. Dietary total SFA (highest vs. lowest quintile, HRQ5vs.Q1 =0.80; 95%CI:0.69-0.92), myristic acid (HRQ5vs.Q1 =0.83, 95%CI:0.74-0.93) and palmitic acid (HRQ5vs.Q1 =0.81, 95%CI:0.70-0.93) were inversely associated with CRC risk. Plasma myristic acid was also inversely associated with colon cancer risk (highest vs. lowest quartile, ORQ4vs.Q1 =0.51; 95%CI:0.32-0.83), whereas a borderline positive association was found for plasma stearic acid (ORQ4vs.Q1 =1.63; 95%CI:1.00-2.64). Dietary total MUFA was inversely associated with colon cancer (per one-standard deviation increment, HR1-SD =0.92, 95%CI: 0.85-0.98), but not rectal cancer (HR1-SD =1.04, 95%CI:0.95-1.15, Pheterogeneity =0.027). Dietary iTFA, and particularly elaidic acid, was positively associated with rectal cancer (HR1-SD =1.07, 95%CI:1.02-1.13). Our results suggest that total and individual saturated fatty acids and fatty acids of industrial origin may be relevant to the aetiology of CRC. Both dietary and plasma myristic acid levels were inversely associated with colon cancer risk, which warrants further investigation.
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000168554 650_7 $$2Other$$abiomarker
000168554 650_7 $$2Other$$acolorectal cancer
000168554 650_7 $$2Other$$adietary intake
000168554 650_7 $$2Other$$afatty acids
000168554 7001_ $$00000-0003-3347-8249$$aMurphy, Neil$$b1
000168554 7001_ $$aHuybrechts, Inge$$b2
000168554 7001_ $$aNicolas, Geneviève$$b3
000168554 7001_ $$aCasagrande, Corinne$$b4
000168554 7001_ $$00000-0002-7805-9913$$aFedirko, Veronika$$b5
000168554 7001_ $$00000-0003-2237-0128$$aWeiderpass, Elisabete$$b6
000168554 7001_ $$aRothwell, Joseph A$$b7
000168554 7001_ $$aDahm, Christina C$$b8
000168554 7001_ $$aOlsen, Anja$$b9
000168554 7001_ $$aTjønneland, Anne$$b10
000168554 7001_ $$0P:(DE-He78)4b2dc91c9d1ac33a1c0e0777d0c1697a$$aKaaks, Rudolf$$b11$$udkfz
000168554 7001_ $$0P:(DE-He78)fb68a9386399d72d84f7f34cfc6048b4$$aKatzke, Verena$$b12$$udkfz
000168554 7001_ $$aSchulze, Matthias B$$b13
000168554 7001_ $$aMasala, Giovanna$$b14
000168554 7001_ $$aAgnoli, Claudia$$b15
000168554 7001_ $$aPanico, Salvatore$$b16
000168554 7001_ $$aTumino, Rosario$$b17
000168554 7001_ $$00000-0002-8008-5096$$aSacerdote, Carlotta$$b18
000168554 7001_ $$aBueno-de-Mesquita, Bas H$$b19
000168554 7001_ $$aDerksen, Jeroen W G$$b20
000168554 7001_ $$aSkeie, Guri$$b21
000168554 7001_ $$aGram, Inger Torhild$$b22
000168554 7001_ $$aBrustad, Magritt$$b23
000168554 7001_ $$00000-0003-0672-8847$$aJakszyn, Paula$$b24
000168554 7001_ $$aSánchez, Maria-Jose$$b25
000168554 7001_ $$aAmiano, Pilar$$b26
000168554 7001_ $$aHuerta, José María$$b27
000168554 7001_ $$aEricson, Ulrika$$b28
000168554 7001_ $$aWennberg, Maria$$b29
000168554 7001_ $$aPerez-Cornago, Aurora$$b30
000168554 7001_ $$00000-0001-6517-1300$$aHeath, Alicia K$$b31
000168554 7001_ $$aJenab, Mazda$$b32
000168554 7001_ $$00000-0003-1297-3064$$aChajes, Veronique$$b33
000168554 7001_ $$aGunter, Marc J$$b34
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