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@ARTICLE{Aglago:168554,
      author       = {E. K. Aglago and N. Murphy and I. Huybrechts and G. Nicolas
                      and C. Casagrande and V. Fedirko and E. Weiderpass and J. A.
                      Rothwell and C. C. Dahm and A. Olsen and A. Tjønneland and
                      R. Kaaks$^*$ and V. Katzke$^*$ and M. B. Schulze and G.
                      Masala and C. Agnoli and S. Panico and R. Tumino and C.
                      Sacerdote and B. H. Bueno-de-Mesquita and J. W. G. Derksen
                      and G. Skeie and I. T. Gram and M. Brustad and P. Jakszyn
                      and M.-J. Sánchez and P. Amiano and J. M. Huerta and U.
                      Ericson and M. Wennberg and A. Perez-Cornago and A. K. Heath
                      and M. Jenab and V. Chajes and M. J. Gunter},
      title        = {{D}ietary intake and plasma phospholipid concentrations of
                      saturated, monounsaturated and trans fatty acids and
                      colorectal cancer risk in the {EPIC} cohort.},
      journal      = {International journal of cancer},
      volume       = {149},
      number       = {4},
      issn         = {1097-0215},
      address      = {Bognor Regis},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2021-00971},
      pages        = {865-882},
      year         = {2021},
      note         = {Volume149, Issue 4 15 August 2021 Pages 865-882},
      abstract     = {Epidemiologic studies examining the association between
                      specific fatty acids and colorectal cancer (CRC) risk are
                      inconclusive. We investigated the association between
                      dietary estimates and plasma levels of individual and total
                      saturated (SFA), monounsaturated (MUFA),
                      industrial-processed trans (iTFA), and ruminant-sourced
                      trans (rTFA) fatty acids, and CRC risk in the European
                      Prospective Investigation into Cancer and Nutrition (EPIC).
                      Baseline fatty acid intakes were estimated in 450,112
                      participants (6,162 developed CRC, median follow-up=15
                      years). In a nested case-control study, plasma phospholipid
                      fatty acids were determined by gas chromatography in 433
                      colon cancer cases and 433 matched controls.
                      Multivariable-adjusted hazard ratios (HRs) and odds ratios
                      (ORs) with $95\%$ confidence intervals (CIs) were computed
                      using Cox and conditional logistic regression, respectively.
                      Dietary total SFA (highest vs. lowest quintile, HRQ5vs.Q1
                      =0.80; $95\%CI:0.69-0.92),$ myristic acid (HRQ5vs.Q1 =0.83,
                      $95\%CI:0.74-0.93)$ and palmitic acid (HRQ5vs.Q1 =0.81,
                      $95\%CI:0.70-0.93)$ were inversely associated with CRC risk.
                      Plasma myristic acid was also inversely associated with
                      colon cancer risk (highest vs. lowest quartile, ORQ4vs.Q1
                      =0.51; $95\%CI:0.32-0.83),$ whereas a borderline positive
                      association was found for plasma stearic acid (ORQ4vs.Q1
                      =1.63; $95\%CI:1.00-2.64).$ Dietary total MUFA was inversely
                      associated with colon cancer (per one-standard deviation
                      increment, HR1-SD =0.92, $95\%CI:$ 0.85-0.98), but not
                      rectal cancer (HR1-SD =1.04, $95\%CI:0.95-1.15,$
                      Pheterogeneity =0.027). Dietary iTFA, and particularly
                      elaidic acid, was positively associated with rectal cancer
                      (HR1-SD =1.07, $95\%CI:1.02-1.13).$ Our results suggest that
                      total and individual saturated fatty acids and fatty acids
                      of industrial origin may be relevant to the aetiology of
                      CRC. Both dietary and plasma myristic acid levels were
                      inversely associated with colon cancer risk, which warrants
                      further investigation.},
      keywords     = {biomarker (Other) / colorectal cancer (Other) / dietary
                      intake (Other) / fatty acids (Other)},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33913149},
      doi          = {10.1002/ijc.33615},
      url          = {https://inrepo02.dkfz.de/record/168554},
}