000168678 001__ 168678
000168678 005__ 20240229133612.0
000168678 0247_ $$2doi$$a10.14309/ajg.0000000000001146
000168678 0247_ $$2pmid$$apmid:33929378
000168678 0247_ $$2ISSN$$a0002-9270
000168678 0247_ $$2ISSN$$a1572-0241
000168678 0247_ $$2altmetric$$aaltmetric:100886574
000168678 037__ $$aDKFZ-2021-00986
000168678 041__ $$aEnglish
000168678 082__ $$a610
000168678 1001_ $$0P:(DE-He78)0311ebf3415e41860b4e2c56fbae6919$$aGuo, Feng$$b0$$eFirst author$$udkfz
000168678 245__ $$aStrong Reduction of Colorectal Cancer Incidence and Mortality After Screening Colonoscopy: Prospective Cohort Study From Germany.
000168678 260__ $$aAlphen aan den Rijn, The Netherlands$$bWolters Kluwer Health, Inc.$$c2021
000168678 3367_ $$2DRIVER$$aarticle
000168678 3367_ $$2DataCite$$aOutput Types/Journal article
000168678 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1620224517_3861
000168678 3367_ $$2BibTeX$$aARTICLE
000168678 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000168678 3367_ $$00$$2EndNote$$aJournal Article
000168678 500__ $$a#EA:C070#LA:C070#
000168678 520__ $$aA claimed advantage of colonoscopy over sigmoidoscopy in colorectal cancer (CRC) screening is prevention of CRC not only in the distal colon and rectum but also in the proximal colon. We aimed to assess the association of screening colonoscopy use with overall and site-specific CRC incidence and associated mortality.Information on use of screening colonoscopy as well as potential confounding factors was obtained at baseline in 2000-2002, updated at 2-, 5-, 8-, and 17-year follow-up from 9,207 participants aged 50-75 years without history of CRC in a statewide cohort study in Saarland, Germany. Covariate-adjusted associations of screening colonoscopy with CRC incidence and mortality, which were obtained through record linkage with the Saarland Cancer Registry and mortality statistics up to 2018, were assessed by Cox proportional hazards models with time-varying exposure information.During a median follow-up of 17.2 years, 268 participants were diagnosed with CRC and 98 died from CRC. Screening colonoscopy was associated with strongly reduced CRC incidence (adjusted hazard ratio [aHR] 0.44, 95% confidence interval [CI] 0.33-0.57) and mortality (aHR 0.34, 95% CI 0.21-0.53), with stronger reduction for distal (aHRs 0.36, 95% CI 0.25-0.51, and 0.33, 95% CI 0.19-0.59, respectively) than for proximal cancer (aHRs 0.69, 95% CI 0.42-1.13, and 0.62, 95% CI 0.26-1.45, respectively). Nevertheless, strong reduction of mortality from proximal cancer was also observed within 10 years after screening colonoscopy (aHR 0.31, 95% CI 0.10-0.96).In this large prospective cohort study from Germany, screening colonoscopy was associated with strong reduction in CRC incidence and mortality.
000168678 536__ $$0G:(DE-HGF)POF4-313$$a313 - Krebsrisikofaktoren und Prävention (POF4-313)$$cPOF4-313$$fPOF IV$$x0
000168678 588__ $$aDataset connected to CrossRef, PubMed, , Journals: inrepo01.inet.dkfz-heidelberg.de
000168678 7001_ $$0P:(DE-He78)b3928caa1d0865f09ffc5cf5e7683da6$$aChen, Chen$$b1
000168678 7001_ $$aHolleczek, Bernd$$b2
000168678 7001_ $$0P:(DE-He78)c67a12496b8aac150c0eef888d808d46$$aSchöttker, Ben$$b3$$udkfz
000168678 7001_ $$0P:(DE-He78)6c5d058b7552d071a7fa4c5e943fff0f$$aHoffmeister, Michael$$b4$$udkfz
000168678 7001_ $$0P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aBrenner, Hermann$$b5$$eLast author$$udkfz
000168678 773__ $$0PERI:(DE-600)2003227-4$$a10.14309/ajg.0000000000001146$$gVol. 116, no. 5, p. 967 - 975$$n5$$p967 - 975$$tThe American journal of gastroenterology$$v116$$x1572-0241$$y2021
000168678 909CO $$ooai:inrepo02.dkfz.de:168678$$pVDB
000168678 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)0311ebf3415e41860b4e2c56fbae6919$$aDeutsches Krebsforschungszentrum$$b0$$kDKFZ
000168678 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)b3928caa1d0865f09ffc5cf5e7683da6$$aDeutsches Krebsforschungszentrum$$b1$$kDKFZ
000168678 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)c67a12496b8aac150c0eef888d808d46$$aDeutsches Krebsforschungszentrum$$b3$$kDKFZ
000168678 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)6c5d058b7552d071a7fa4c5e943fff0f$$aDeutsches Krebsforschungszentrum$$b4$$kDKFZ
000168678 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aDeutsches Krebsforschungszentrum$$b5$$kDKFZ
000168678 9130_ $$0G:(DE-HGF)POF3-313$$1G:(DE-HGF)POF3-310$$2G:(DE-HGF)POF3-300$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vCancer risk factors and prevention$$x0
000168678 9131_ $$0G:(DE-HGF)POF4-313$$1G:(DE-HGF)POF4-310$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vKrebsrisikofaktoren und Prävention$$x0
000168678 9141_ $$y2021
000168678 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bAM J GASTROENTEROL : 2019$$d2021-02-05
000168678 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2021-02-05
000168678 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2021-02-05
000168678 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2021-02-05
000168678 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2021-02-05
000168678 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2021-02-05
000168678 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2021-02-05
000168678 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2021-02-05
000168678 915__ $$0StatID:(DE-HGF)1110$$2StatID$$aDBCoverage$$bCurrent Contents - Clinical Medicine$$d2021-02-05
000168678 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2021-02-05
000168678 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2021-02-05
000168678 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2021-02-05
000168678 915__ $$0StatID:(DE-HGF)9910$$2StatID$$aIF >= 10$$bAM J GASTROENTEROL : 2019$$d2021-02-05
000168678 9201_ $$0I:(DE-He78)C070-20160331$$kC070$$lC070 Klinische Epidemiologie und Alternf.$$x0
000168678 9201_ $$0I:(DE-He78)C120-20160331$$kC120$$lPräventive Onkologie$$x1
000168678 9201_ $$0I:(DE-He78)HD01-20160331$$kHD01$$lDKTK HD zentral$$x2
000168678 980__ $$ajournal
000168678 980__ $$aVDB
000168678 980__ $$aI:(DE-He78)C070-20160331
000168678 980__ $$aI:(DE-He78)C120-20160331
000168678 980__ $$aI:(DE-He78)HD01-20160331
000168678 980__ $$aUNRESTRICTED