%0 Journal Article
%A Brenner, Hermann
%A Kuznia, Sabine
%A Laetsch, Clarissa
%A Niedermaier, Tobias
%A Schöttker, Ben
%T Prevention of Advanced Cancer by Vitamin D3 Supplementation: Interaction by Body Mass Index Revisited.
%J Nutrients
%V 13
%N 5
%@ 2072-6643
%C Basel
%I MDPI
%M DKFZ-2021-00996
%P 1408
%D 2021
%Z #EA:C070#LA:C070#
%X Meta-analyses of randomized controlled trials (RCTs) have demonstrated a protective effect of vitamin D3 (cholecalciferol) supplementation against cancer mortality. In the VITAL study, a RCT including 25,871 men ≥ 50 years and women ≥ 55 years, protective effects of vitamin D3 supplementation (2000 IU/day over a median of 5.3 years) with respect to incidence of any cancer and of advanced cancer (metastatic cancer or cancer death) were seen for normal-weight participants but not for overweight or obese participants. We aimed to explore potential reasons for this apparent variation of vitamin D effects by body mass index. We conducted complementary analyses of published data from the VITAL study on the association of body weight with cancer outcomes, stratified by vitamin D3 supplementation. Significantly increased risks of any cancer and of advanced cancer were seen among normal-weight participants compared to obese participants in the control group (relative risk (RR), 1.27; 95
%K body mass index (Other)
%K cancer (Other)
%K prevention (Other)
%K supplementation (Other)
%K vitamin D (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:33922032
%R 10.3390/nu13051408
%U https://inrepo02.dkfz.de/record/168688