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@ARTICLE{Pannen:168695,
      author       = {S. Pannen and S. G. Maldonado$^*$ and T. Nonnenmacher$^*$
                      and S. A. Sowah$^*$ and L. F. Gruner$^*$ and C.
                      Watzinger$^*$ and K. Nischwitz and C. M. Ulrich and R.
                      Kaaks$^*$ and R. Schübel$^*$ and M. Grafetstätter$^*$ and
                      T. Kühn$^*$},
      title        = {{A}dherence and {D}ietary {C}omposition during
                      {I}ntermittent vs. {C}ontinuous {C}alorie {R}estriction:
                      {F}ollow-{U}p {D}ata from a {R}andomized {C}ontrolled
                      {T}rial in {A}dults with {O}verweight or {O}besity.},
      journal      = {Nutrients},
      volume       = {13},
      number       = {4},
      issn         = {2072-6643},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DKFZ-2021-01003},
      pages        = {1195},
      year         = {2021},
      note         = {#EA:C020#LA:C020#},
      abstract     = {Although intermittent calorie restriction (ICR) has become
                      popular as an alternative weight loss strategy to continuous
                      calorie restriction (CCR), there is insufficient evidence on
                      diet quality during ICR and on its feasibility over longer
                      time periods. Thus, we compared dietary composition and
                      adherence between ICR and CCR in a follow-up analysis of a
                      randomized trial. A total of 98 participants with overweight
                      or obesity [BMI (kg/m2) 25-39.9, 35-65 years, $49\%$
                      females] were randomly assigned to ICR, operationalized as a
                      '5:2 diet' (energy intake: $~100\%$ on five non-restricted
                      (NR) days, $~25\%$ on two restricted (R) days), or CCR
                      (daily energy intake: $~80\%).$ The trial included a 12-week
                      (wk) intervention phase, and follow-up assessments at wk24,
                      wk50 and wk102. Apart from a higher proportion of energy
                      intake from protein with ICR vs. CCR during the intervention
                      (wk2: p < 0.001; wk12: p = 0.002), there were no significant
                      differences with respect to changes in dietary composition
                      over time between the groups, while overall adherence to the
                      interventions appeared to be good. No significant difference
                      between ICR and CCR regarding weight change at wk102 was
                      observed (p = 0.63). However, self-reported adherence was
                      worse for ICR than CCR, with $71.1\%$ vs. $32.5\%$ of the
                      participants reporting not to or only rarely have followed
                      the regimen to which they were assigned between wk50 and
                      wk102. These results indicate that within a weight
                      management setting, ICR and CCR were equivalent in achieving
                      modest weight loss over two years while affecting dietary
                      composition in a comparable manner.},
      keywords     = {compliance (Other) / diet quality (Other) / energy intake
                      (Other) / fasting (Other) / food records (Other) /
                      intermittent energy restriction (Other) / obesity (Other) /
                      weight loss (Other)},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33916366},
      pmc          = {pmc:PMC8067073},
      doi          = {10.3390/nu13041195},
      url          = {https://inrepo02.dkfz.de/record/168695},
}