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| Home > Publications database > 68Ga-FAPI-PET/CT improves diagnostic staging and radiotherapy planning of Adenoid Cystic Carcinomas - imaging analysis and histological validation. > print |
| Home > Publications database > 68Ga-FAPI-PET/CT improves diagnostic staging and radiotherapy planning of Adenoid Cystic Carcinomas - imaging analysis and histological validation. > print |
| 001 | 168701 | ||
| 005 | 20240917145525.0 | ||
| 024 | 7 | _ | |a 10.1016/j.radonc.2021.04.016 |2 doi |
| 024 | 7 | _ | |a pmid:33940087 |2 pmid |
| 024 | 7 | _ | |a 0167-8140 |2 ISSN |
| 024 | 7 | _ | |a 1879-0887 |2 ISSN |
| 024 | 7 | _ | |a altmetric:106390463 |2 altmetric |
| 037 | _ | _ | |a DKFZ-2021-01009 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Röhrich, Manuel |b 0 |
| 245 | _ | _ | |a 68Ga-FAPI-PET/CT improves diagnostic staging and radiotherapy planning of Adenoid Cystic Carcinomas - imaging analysis and histological validation. |
| 260 | _ | _ | |a Amsterdam [u.a.] |c 2021 |b Elsevier Science |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1726577701_16365 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
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| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 500 | _ | _ | |a 2021 May 1;160:192-201 |
| 520 | _ | _ | |a Adenoid cystic carcinomas (ACCs) are rare epithelial tumors mostly situated in the head and neck region and characterized by infiltrative growth. The tumor stroma of ACCs includes cancer-associated fibroblasts (CAFs) expressing Fibroblast Activation Protein (FAP), a new target for positron emission tomography (PET) imaging. Here we describe the value of PET/ computed tomography (PET/CT) imaging using 68Ga-labelled FAP-Inhibitors (68Ga-FAPI-PET/CT) and their clinical potential for staging and radiotherapy planning in 12 ACC patients (7 primary, 5 recurrent).Patients underwent contrast enhanced staging CT (ceCT) and magnetic resonance imaging (ceMRI) before 68Ga-FAPI - PET/CT. PET-scans were acquired 10, 60 and 180 minutes after administration of 150-250 MBq of 68Ga-labelled FAPI tracers. SUVmax and SUVmean values of ACCs and healthy organs were obtained using a 60% of maximum iso-contour. FAP and alpha smooth muscle actin (α-SMA) immunohistochemistry was performed in 13 cases (3 with and 10 without 68Ga FAPI-PET/CT). Staging and radiotherapy planning based on 68Ga-FAPI-PET/CT versus ceCT/MRI alone were compared.We observed elevated tracer uptake in all ACCs. Immunohistochemistry showed FAP-expressing CAFs in the tumor. Compared to conventional staging, 68Ga-FAPI-PET/CT led to upstaging in 2/12 patients and to detection of additional metastases in 3 patients, thus in total 42% of patients had their staging altered. Moreover, 68Ga-FAPI PET improved the accuracy of target volume delineation for radiotherapy, as compared to CT and MRI.68Ga-FAPI-PET/CT is a promising imaging modality for ACC, increasing the accuracy of staging exams and radiotherapy planning volumes, as compared conventional to CT and MRI. |
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| 650 | _ | 7 | |a ACC |2 Other |
| 650 | _ | 7 | |a Adenoid cystic carcinoma |2 Other |
| 650 | _ | 7 | |a FAP |2 Other |
| 650 | _ | 7 | |a Fibroblast Activation Protein |2 Other |
| 650 | _ | 7 | |a Positron Emission Tomography |2 Other |
| 650 | _ | 7 | |a Radiotherapy |2 Other |
| 650 | _ | 7 | |a Staging |2 Other |
| 650 | _ | 7 | |a TNM |2 Other |
| 650 | _ | 7 | |a alpha SMA |2 Other |
| 700 | 1 | _ | |a Syed, Mustafa |b 1 |
| 700 | 1 | _ | |a Liew, Dawn P |b 2 |
| 700 | 1 | _ | |a Giesel, Frederik L |0 P:(DE-He78)5ca7e97b2769bb97f8c73431c6566b94 |b 3 |
| 700 | 1 | _ | |a Liermann, Jakob |b 4 |
| 700 | 1 | _ | |a Choyke, Peter L |b 5 |
| 700 | 1 | _ | |a Wefers, Annika K |0 P:(DE-He78)32977c5abc127b0373ece54294a41f63 |b 6 |
| 700 | 1 | _ | |a Ritz, Thomas |b 7 |
| 700 | 1 | _ | |a Szymbara, Marina |0 P:(DE-He78)fb880577e0932ea92d81172263f291f0 |b 8 |
| 700 | 1 | _ | |a Schillings, Lisa |b 9 |
| 700 | 1 | _ | |a Heger, Ulrike |b 10 |
| 700 | 1 | _ | |a Rathke, Hendrik |b 11 |
| 700 | 1 | _ | |a Kratochwil, Clemens |b 12 |
| 700 | 1 | _ | |a Huber, Peter E |0 P:(DE-He78)3291aaac20f3d603d96744c1f0890028 |b 13 |u dkfz |
| 700 | 1 | _ | |a von Deimling, Andreas |0 P:(DE-He78)a8a10626a848d31e70cfd96a133cc144 |b 14 |
| 700 | 1 | _ | |a Debus, Jürgen |b 15 |
| 700 | 1 | _ | |a Kauczor, Hans-Ulrich |b 16 |
| 700 | 1 | _ | |a Haberkorn, Uwe |0 P:(DE-He78)13a0afba029f5f64dc18b25ef7499558 |b 17 |
| 700 | 1 | _ | |a Adeberg, Sebastian |0 P:(DE-HGF)0 |b 18 |
| 773 | _ | _ | |a 10.1016/j.radonc.2021.04.016 |g p. S0167814021062137 |0 PERI:(DE-600)1500707-8 |p 192-201 |t Radiotherapy and oncology |v 160 |y 2021 |x 0167-8140 |
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