TY  - JOUR
AU  - Stoian, Raluca
AU  - Erbes, Thalia
AU  - Zamboglou, Constantinos
AU  - Scholber, Jutta
AU  - Gainey, Mark
AU  - Sachpazidis, Ilias
AU  - Haehl, Erik
AU  - Spohn, Simon K B
AU  - Verma, Vivek
AU  - Krug, David
AU  - Rühle, Alexander
AU  - Juhasz-Böss, Ingolf
AU  - Grosu, Anca-Ligia
AU  - Nicolay, Nils H
AU  - Sprave, Tanja
TI  - Intraoperative radiotherapy boost as part of breast-conservation therapy for breast cancer: a single-institution retrospective analysis.
JO  - Strahlentherapie und Onkologie
VL  - 197
IS  - 9
SN  - 1439-099X
CY  - Heidelberg
PB  - Springer Medizin
M1  - DKFZ-2021-01011
SP  - 812-819
PY  - 2021
N1  -  2021 Sep;197(9):812-819
AB  - There are currently no data from randomized controlled trials on the use of intraoperative radiotherapy (IORT) as a tumor bed boost as part of a breast-conservation approach for breast cancer. This study retrospectively reviewed the safety and efficacy of IORT as a boost treatment at a tertiary cancer center.From 2015 to 2019, patients underwent breast-conserving surgery with axillary lymph node staging and a single dose of 20 Gy IORT with 50-kV photons, followed by whole-breast irradiation (WBI) and adjuvant systemic therapy (if applicable). Patients were followed for assessment of acute and late toxicities (using the Common Terminology Criteria for Adverse Events version 5.0) at 3-6-month intervals. Outcomes included ipsilateral (IBTR) and contralateral breast progression-free survival (CBE), distant metastasis-free survival (DMFS), and overall survival (OS).Median follow-up for the 214 patients was 28 (range 2-59) months. Most patients had T1 disease (n = 124) and were clinically node negative. Only few patients had high-grade and/or triple-negative disease. The vast majority of patients underwent sentinel node biopsy, and 32 (15
KW  - Adjuvant radiation therapy (Other)
KW  - Boost (Other)
KW  - Breast-conservation therapy (Other)
KW  - Early breast cancer (Other)
KW  - Intraoperative radiotherapy (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:33938966
DO  - DOI:10.1007/s00066-021-01785-2
UR  - https://inrepo02.dkfz.de/record/168703
ER  -