%0 Journal Article
%A Zin, Francesca
%A Cotter, Jennifer A
%A Haberler, Christine
%A Dottermusch, Matthias
%A Neumann, Julia
%A Schüller, Ulrich
%A Schweizer, Leonille
%A Thomas, Christian
%A Nemes, Karolina
%A Johann, Pascal D
%A Kool, Marcel
%A Frühwald, Michael C
%A Paulus, Werner
%A Judkins, Alexander
%A Hasselblatt, Martin
%T Histopathological patterns in atypical teratoid/rhabdoid tumors are related to molecular subgroup.
%J Brain pathology
%V 31
%N 5
%@ 1750-3639
%C Oxford
%I Wiley-Blackwell
%M DKFZ-2021-01012
%P e12967
%D 2021
%Z 2021 Sep;31(5):e12967
%X Atypical teratoid/rhabdoid tumor (AT/RT) is a highly malignant tumor that may not only contain rhabdoid tumor cells but also poorly differentiated small-round-blue cells as well as areas with mesenchymal or epithelial differentiation. Little is known on factors associated with histopathological diversity. Recent studies demonstrated three molecular subgroups of AT/RT, namely ATRT-TYR, ATRT-SHH, and ATRT-MYC. We thus aimed to investigate if morphological patterns might be related to molecular subgroup status. Hematoxylin-eosin stained sections of 114 AT/RT with known molecular subgroup status were digitalized and independently categorized by nine blinded observers into four morphological categories, that is, 'rhabdoid,' 'small-round-blue,' 'epithelial,' and 'mesenchymal.' The series comprised 48 ATRT-SHH, 40 ATRT-TYR, and 26 ATRT-MYC tumors. Inter-observer agreement was moderate but significant (Fleiss' kappa = 0.47; 95
%K AT/RT (Other)
%K DNA methylation profiling (Other)
%K INI-1 (Other)
%K cytokeratin (Other)
%K histopathology (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:33938067
%R 10.1111/bpa.12967
%U https://inrepo02.dkfz.de/record/168704