TY  - JOUR
AU  - Zin, Francesca
AU  - Cotter, Jennifer A
AU  - Haberler, Christine
AU  - Dottermusch, Matthias
AU  - Neumann, Julia
AU  - Schüller, Ulrich
AU  - Schweizer, Leonille
AU  - Thomas, Christian
AU  - Nemes, Karolina
AU  - Johann, Pascal D
AU  - Kool, Marcel
AU  - Frühwald, Michael C
AU  - Paulus, Werner
AU  - Judkins, Alexander
AU  - Hasselblatt, Martin
TI  - Histopathological patterns in atypical teratoid/rhabdoid tumors are related to molecular subgroup.
JO  - Brain pathology
VL  - 31
IS  - 5
SN  - 1750-3639
CY  - Oxford
PB  - Wiley-Blackwell
M1  - DKFZ-2021-01012
SP  - e12967
PY  - 2021
N1  - 2021 Sep;31(5):e12967
AB  - Atypical teratoid/rhabdoid tumor (AT/RT) is a highly malignant tumor that may not only contain rhabdoid tumor cells but also poorly differentiated small-round-blue cells as well as areas with mesenchymal or epithelial differentiation. Little is known on factors associated with histopathological diversity. Recent studies demonstrated three molecular subgroups of AT/RT, namely ATRT-TYR, ATRT-SHH, and ATRT-MYC. We thus aimed to investigate if morphological patterns might be related to molecular subgroup status. Hematoxylin-eosin stained sections of 114 AT/RT with known molecular subgroup status were digitalized and independently categorized by nine blinded observers into four morphological categories, that is, 'rhabdoid,' 'small-round-blue,' 'epithelial,' and 'mesenchymal.' The series comprised 48 ATRT-SHH, 40 ATRT-TYR, and 26 ATRT-MYC tumors. Inter-observer agreement was moderate but significant (Fleiss' kappa = 0.47; 95
KW  - AT/RT (Other)
KW  - DNA methylation profiling (Other)
KW  - INI-1 (Other)
KW  - cytokeratin (Other)
KW  - histopathology (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:33938067
DO  - DOI:10.1111/bpa.12967
UR  - https://inrepo02.dkfz.de/record/168704
ER  -