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@ARTICLE{Zin:168704,
      author       = {F. Zin and J. A. Cotter and C. Haberler and M. Dottermusch
                      and J. Neumann and U. Schüller and L. Schweizer and C.
                      Thomas and K. Nemes and P. D. Johann$^*$ and M. Kool$^*$ and
                      M. C. Frühwald and W. Paulus and A. Judkins and M.
                      Hasselblatt},
      title        = {{H}istopathological patterns in atypical teratoid/rhabdoid
                      tumors are related to molecular subgroup.},
      journal      = {Brain pathology},
      volume       = {31},
      number       = {5},
      issn         = {1750-3639},
      address      = {Oxford},
      publisher    = {Wiley-Blackwell},
      reportid     = {DKFZ-2021-01012},
      pages        = {e12967},
      year         = {2021},
      note         = {2021 Sep;31(5):e12967},
      abstract     = {Atypical teratoid/rhabdoid tumor (AT/RT) is a highly
                      malignant tumor that may not only contain rhabdoid tumor
                      cells but also poorly differentiated small-round-blue cells
                      as well as areas with mesenchymal or epithelial
                      differentiation. Little is known on factors associated with
                      histopathological diversity. Recent studies demonstrated
                      three molecular subgroups of AT/RT, namely ATRT-TYR,
                      ATRT-SHH, and ATRT-MYC. We thus aimed to investigate if
                      morphological patterns might be related to molecular
                      subgroup status. Hematoxylin-eosin stained sections of 114
                      AT/RT with known molecular subgroup status were digitalized
                      and independently categorized by nine blinded observers into
                      four morphological categories, that is, 'rhabdoid,'
                      'small-round-blue,' 'epithelial,' and 'mesenchymal.' The
                      series comprised 48 ATRT-SHH, 40 ATRT-TYR, and 26 ATRT-MYC
                      tumors. Inter-observer agreement was moderate but
                      significant (Fleiss' kappa = 0.47; $95\%$ C.I. 0.41-0.53;
                      p < 0.001) and there was a highly significant overall
                      association between morphological categories and molecular
                      subgroups for each of the nine observers (p < 0.0001).
                      Specifically, the category 'epithelial' was found to be
                      over-represented in ATRT-TYR (p < 0.000001) and the
                      category 'small-round-blue' to be over-represented in
                      ATRT-SHH (p < 0.01). The majority of ATRT-MYC was
                      categorized as 'mesenchymal' or 'rhabdoid,' but this
                      association was less compelling. The specificity of the
                      category 'epithelial' for ATRT-TYR was highest and accounted
                      for $97\%$ (range: $88-99\%)$ whereas sensitivity was low
                      $[49\%$ (range: $35\%-63\%)].$ In line with these findings,
                      cytokeratin-positivity was highly overrepresented in
                      ATRT-TYR. In conclusion, morphological features of AT/RT
                      might reflect molecular alterations and may also provide a
                      first hint on molecular subgroup status, which will need to
                      be confirmed by DNA methylation profiling.},
      keywords     = {AT/RT (Other) / DNA methylation profiling (Other) / INI-1
                      (Other) / cytokeratin (Other) / histopathology (Other)},
      cin          = {B062 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)B062-20160331 / I:(DE-He78)HD01-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33938067},
      doi          = {10.1111/bpa.12967},
      url          = {https://inrepo02.dkfz.de/record/168704},
}