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| 001 | 168704 | ||
| 005 | 20240229133613.0 | ||
| 024 | 7 | _ | |a 10.1111/bpa.12967 |2 doi |
| 024 | 7 | _ | |a pmid:33938067 |2 pmid |
| 024 | 7 | _ | |a 1015-6305 |2 ISSN |
| 024 | 7 | _ | |a 1750-3639 |2 ISSN |
| 024 | 7 | _ | |a altmetric:105214859 |2 altmetric |
| 037 | _ | _ | |a DKFZ-2021-01012 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Zin, Francesca |b 0 |
| 245 | _ | _ | |a Histopathological patterns in atypical teratoid/rhabdoid tumors are related to molecular subgroup. |
| 260 | _ | _ | |a Oxford |c 2021 |b Wiley-Blackwell |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1634304293_1826 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 500 | _ | _ | |a 2021 Sep;31(5):e12967 |
| 520 | _ | _ | |a Atypical teratoid/rhabdoid tumor (AT/RT) is a highly malignant tumor that may not only contain rhabdoid tumor cells but also poorly differentiated small-round-blue cells as well as areas with mesenchymal or epithelial differentiation. Little is known on factors associated with histopathological diversity. Recent studies demonstrated three molecular subgroups of AT/RT, namely ATRT-TYR, ATRT-SHH, and ATRT-MYC. We thus aimed to investigate if morphological patterns might be related to molecular subgroup status. Hematoxylin-eosin stained sections of 114 AT/RT with known molecular subgroup status were digitalized and independently categorized by nine blinded observers into four morphological categories, that is, 'rhabdoid,' 'small-round-blue,' 'epithelial,' and 'mesenchymal.' The series comprised 48 ATRT-SHH, 40 ATRT-TYR, and 26 ATRT-MYC tumors. Inter-observer agreement was moderate but significant (Fleiss' kappa = 0.47; 95% C.I. 0.41-0.53; p < 0.001) and there was a highly significant overall association between morphological categories and molecular subgroups for each of the nine observers (p < 0.0001). Specifically, the category 'epithelial' was found to be over-represented in ATRT-TYR (p < 0.000001) and the category 'small-round-blue' to be over-represented in ATRT-SHH (p < 0.01). The majority of ATRT-MYC was categorized as 'mesenchymal' or 'rhabdoid,' but this association was less compelling. The specificity of the category 'epithelial' for ATRT-TYR was highest and accounted for 97% (range: 88-99%) whereas sensitivity was low [49% (range: 35%-63%)]. In line with these findings, cytokeratin-positivity was highly overrepresented in ATRT-TYR. In conclusion, morphological features of AT/RT might reflect molecular alterations and may also provide a first hint on molecular subgroup status, which will need to be confirmed by DNA methylation profiling. |
| 536 | _ | _ | |a 312 - Funktionelle und strukturelle Genomforschung (POF4-312) |0 G:(DE-HGF)POF4-312 |c POF4-312 |f POF IV |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, , Journals: inrepo01.inet.dkfz-heidelberg.de |
| 650 | _ | 7 | |a AT/RT |2 Other |
| 650 | _ | 7 | |a DNA methylation profiling |2 Other |
| 650 | _ | 7 | |a INI-1 |2 Other |
| 650 | _ | 7 | |a cytokeratin |2 Other |
| 650 | _ | 7 | |a histopathology |2 Other |
| 700 | 1 | _ | |a Cotter, Jennifer A |b 1 |
| 700 | 1 | _ | |a Haberler, Christine |b 2 |
| 700 | 1 | _ | |a Dottermusch, Matthias |b 3 |
| 700 | 1 | _ | |a Neumann, Julia |b 4 |
| 700 | 1 | _ | |a Schüller, Ulrich |0 0000-0002-8731-1121 |b 5 |
| 700 | 1 | _ | |a Schweizer, Leonille |b 6 |
| 700 | 1 | _ | |a Thomas, Christian |b 7 |
| 700 | 1 | _ | |a Nemes, Karolina |b 8 |
| 700 | 1 | _ | |a Johann, Pascal D |0 P:(DE-He78)3fdc3623477264cb5d0e14f256dbfbb8 |b 9 |u dkfz |
| 700 | 1 | _ | |a Kool, Marcel |0 P:(DE-He78)4c28e2aade5f44d8eca9dd8e97638ec8 |b 10 |u dkfz |
| 700 | 1 | _ | |a Frühwald, Michael C |b 11 |
| 700 | 1 | _ | |a Paulus, Werner |b 12 |
| 700 | 1 | _ | |a Judkins, Alexander |b 13 |
| 700 | 1 | _ | |a Hasselblatt, Martin |0 0000-0003-2707-8484 |b 14 |
| 773 | _ | _ | |a 10.1111/bpa.12967 |0 PERI:(DE-600)2029927-8 |n 5 |p e12967 |t Brain pathology |v 31 |y 2021 |x 1750-3639 |
| 909 | C | O | |p VDB |o oai:inrepo02.dkfz.de:168704 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 9 |6 P:(DE-He78)3fdc3623477264cb5d0e14f256dbfbb8 |
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| 914 | 1 | _ | |y 2021 |
| 915 | _ | _ | |a DEAL Wiley |0 StatID:(DE-HGF)3001 |2 StatID |d 2021-02-02 |w ger |
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| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b BRAIN PATHOL : 2019 |d 2021-02-02 |
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| 915 | _ | _ | |a IF >= 5 |0 StatID:(DE-HGF)9905 |2 StatID |b BRAIN PATHOL : 2019 |d 2021-02-02 |
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