TY  - JOUR
AU  - Lyskjaer, Iben
AU  - De Noon, Solange
AU  - Tirabosco, Roberto
AU  - Rocha, Ana Maia
AU  - Lindsay, Daniel
AU  - Amary, Fernanda
AU  - Ye, Hongtao
AU  - Schrimpf, Daniel
AU  - Stichel, Damian
AU  - Sill, Martin
AU  - Koelsche, Christian
AU  - Pillay, Nischalan
AU  - Von Deimling, Andreas
AU  - Beck, Stephan
AU  - Flanagan, Adrienne M
TI  - DNA methylation-based profiling of bone and soft tissue tumours: a validation study of the 'DKFZ Sarcoma Classifier'.
JO  - The journal of pathology: clinical research
VL  - 7
IS  - 4
SN  - 2056-4538
CY  - Chichester
PB  - Wiley
M1  - DKFZ-2021-01033
SP  - 350-360
PY  - 2021
N1  - 2021 Jul;7(4):350-360
AB  - Diagnosing bone and soft tissue neoplasms remains challenging because of the large number of subtypes, many of which lack diagnostic biomarkers. DNA methylation profiles have proven to be a reliable basis for the classification of brain tumours and, following this success, a DNA methylation-based sarcoma classification tool from the Deutsches Krebsforschungszentrum (DKFZ) in Heidelberg has been developed. In this study, we assessed the performance of their classifier on DNA methylation profiles of an independent data set of 986 bone and soft tissue tumours and controls. We found that the 'DKFZ Sarcoma Classifier' was able to produce a diagnostic prediction for 55
KW  - bone (Other)
KW  - classifier (Other)
KW  - methylation profiling (Other)
KW  - sarcoma (Other)
KW  - soft tissue (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:33949149
DO  - DOI:10.1002/cjp2.215
UR  - https://inrepo02.dkfz.de/record/168739
ER  -