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@ARTICLE{Karabegovi:168829,
      author       = {I. Karabegović and E. Portilla-Fernandez and Y. Li and J.
                      Ma and S. C. E. Maas and D. Sun and E. A. Hu and B. Kühnel
                      and Y. Zhang$^*$ and S. Ambatipudi and G. Fiorito and J.
                      Huang and J. E. Castillo-Fernandez and K. L. Wiggins and N.
                      de Klein and S. Grioni and B. R. Swenson and S. Polidoro and
                      J. L. Treur and C. Cuenin and P.-C. Tsai and R. Costeira and
                      V. Chajes and K. Braun and N. Verweij and A. Kretschmer and
                      L. Franke and J. B. J. van Meurs and A. G. Uitterlinden and
                      R. J. de Knegt and M. A. Ikram and A. Dehghan and A. Peters
                      and B. Schöttker$^*$ and S. A. Gharib and N. Sotoodehnia
                      and J. T. Bell and P. Elliott and P. Vineis and C. Relton
                      and Z. Herceg and H. Brenner$^*$ and M. Waldenberger and C.
                      M. Rebholz and T. Voortman and Q. Pan and M. Fornage and D.
                      Levy and M. Kayser and M. Ghanbari},
      title        = {{E}pigenome-wide association meta-analysis of {DNA}
                      methylation with coffee and tea consumption.},
      journal      = {Nature Communications},
      volume       = {12},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Nature Publishing Group UK},
      reportid     = {DKFZ-2021-01080},
      pages        = {2830},
      year         = {2021},
      abstract     = {Coffee and tea are extensively consumed beverages worldwide
                      which have received considerable attention regarding health.
                      Intake of these beverages is consistently linked to, among
                      others, reduced risk of diabetes and liver diseases;
                      however, the mechanisms of action remain elusive.
                      Epigenetics is suggested as a mechanism mediating the
                      effects of dietary and lifestyle factors on disease onset.
                      Here we report the results from epigenome-wide association
                      studies (EWAS) on coffee and tea consumption in 15,789
                      participants of European and African-American ancestries
                      from 15 cohorts. EWAS meta-analysis of coffee consumption
                      reveals 11 CpGs surpassing the epigenome-wide significance
                      threshold (P-value <1.1×10-7), which annotated to the AHRR,
                      F2RL3, FLJ43663, HDAC4, GFI1 and PHGDH genes. Among them,
                      cg14476101 is significantly associated with expression of
                      the PHGDH and risk of fatty liver disease. Knockdown of
                      PHGDH expression in liver cells shows a correlation with
                      expression levels of genes associated with circulating
                      lipids, suggesting a role of PHGDH in hepatic-lipid
                      metabolism. EWAS meta-analysis on tea consumption reveals no
                      significant association, only two CpGs annotated to CACNA1A
                      and PRDM16 genes show suggestive association (P-value
                      <5.0×10-6). These findings indicate that coffee-associated
                      changes in DNA methylation levels may explain the mechanism
                      of action of coffee consumption in conferring risk of
                      diseases.},
      cin          = {C070 / C120 / HD01},
      ddc          = {500},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)C120-20160331 /
                      I:(DE-He78)HD01-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33990564},
      doi          = {10.1038/s41467-021-22752-6},
      url          = {https://inrepo02.dkfz.de/record/168829},
}