TY  - JOUR
AU  - Archambault, Alexi N
AU  - Lin, Yi
AU  - Jeon, Jihyoun
AU  - Harrison, Tabitha A
AU  - Bishop, D Timothy
AU  - Brenner, Hermann
AU  - Casey, Graham
AU  - Chan, Andrew T
AU  - Chang-Claude, Jenny
AU  - Figueiredo, Jane C
AU  - Gallinger, Steven
AU  - Gruber, Stephen B
AU  - Gunter, Marc J
AU  - Hoffmeister, Michael
AU  - Jenkins, Mark A
AU  - Keku, Temitope O
AU  - Marchand, Loïc Le
AU  - Li, Li
AU  - Moreno, Victor
AU  - Newcomb, Polly A
AU  - Pai, Rish
AU  - Parfrey, Patrick S
AU  - Rennert, Gad
AU  - Sakoda, Lori C
AU  - Sandler, Robert S
AU  - Slattery, Martha L
AU  - Song, Mingyang
AU  - Win, Aung Ko
AU  - Woods, Michael O
AU  - Murphy, Neil
AU  - Campbell, Peter T
AU  - Su, Yu-Ru
AU  - Zeleniuch-Jacquotte, Anne
AU  - Liang, Peter S
AU  - Du, Mengmeng
AU  - Hsu, Li
AU  - Peters, Ulrike
AU  - Hayes, Richard B
TI  - Nongenetic Determinants of Risk for Early-Onset Colorectal Cancer.
JO  - JNCI cancer spectrum
VL  - 5
IS  - 3
SN  - 2515-5091
CY  - Oxford
PB  - Oxford University Press
M1  - DKFZ-2021-01178
SP  - pkab029
PY  - 2021
AB  - Incidence of early-onset (younger than 50 years of age) colorectal cancer (CRC) is increasing in many countries. Thus, elucidating the role of traditional CRC risk factors in early-onset CRC is a high priority. We sought to determine whether risk factors associated with late-onset CRC were also linked to early-onset CRC and whether association patterns differed by anatomic subsite.Using data pooled from 13 population-based studies, we studied 3767 CRC cases and 4049 controls aged younger than 50 years and 23 437 CRC cases and 35 311 controls aged 50 years and older. Using multivariable and multinomial logistic regression, we estimated odds ratios (ORs) and 95
LB  - PUB:(DE-HGF)16
C6  - pmid:34041438
C2  - pmc:PMC8134523
DO  - DOI:10.1093/jncics/pkab029
UR  - https://inrepo02.dkfz.de/record/168982
ER  -