%0 Journal Article %A Cardoso, Rafael %A Guo, Feng %A Heisser, Thomas %A Hackl, Monika %A Ihle, Petra %A De Schutter, Harlinde %A Van Damme, Nancy %A Valerianova, Zdravka %A Atanasov, Trajan %A Májek, Ondřej %A Mužík, Jan %A Nilbert, Mef Christina %A Tybjerg, Anne Julie %A Innos, Kaire %A Mägi, Margit %A Malila, Nea %A Bouvier, Anne-Marie %A Bouvier, Véronique %A Launoy, Guy %A Woronoff, Anne-Sophie %A Cariou, Mélanie %A Robaszkiewicz, Michel %A Delafosse, Patricia %A Poncet, Florence %A Katalinic, Alexander %A Walsh, Paul M %A Senore, Carlo %A Rosso, Stefano %A Vincerževskienė, Ieva %A Lemmens, Valery E P P %A Elferink, Marloes A G %A Johannesen, Tom Børge %A Kørner, Hartwig %A Pfeffer, Frank %A Bento, Maria José %A Rodrigues, Jessica %A Alves da Costa, Filipa %A Miranda, Ana %A Zadnik, Vesna %A Žagar, Tina %A Lopez de Munain Marques, Arantza %A Marcos-Gragera, Rafael %A Puigdemont, Montse %A Galceran, Jaume %A Carulla, Marià %A Chirlaque, María-Dolores %A Ballesta, Monica %A Sundquist, Kristina %A Sundquist, Jan %A Weber, Marco %A Jordan, Andrea %A Herrmann, Christian %A Mousavi, Mohsen %A Ryzhov, Anton %A Hoffmeister, Michael %A Brenner, Hermann %T Colorectal cancer incidence, mortality, and stage distribution in European countries in the colorectal cancer screening era: an international population-based study. %J The lancet / Oncology %V 22 %N 7 %@ 1470-2045 %C London %I The Lancet Publ. Group %M DKFZ-2021-01186 %P 1002-1013 %D 2021 %Z #EA:C120#LA:C070#/2021 Jul;22(7):1002-1013 %X Colorectal cancer screening programmes and uptake vary substantially across Europe. We aimed to compare changes over time in colorectal cancer incidence, mortality, and stage distribution in relation to colorectal cancer screening implementation in European countries.Data from nearly 3·1 million patients with colorectal cancer diagnosed from 2000 onwards (up to 2016 for most countries) were obtained from 21 European countries, and were used to analyse changes over time in age-standardised colorectal cancer incidence and stage distribution. The WHO mortality database was used to analyse changes over time in age-standardised colorectal cancer mortality over the same period for the 16 countries with nationwide data. Incidence rates were calculated for all sites of the colon and rectum combined, as well as the subsites proximal colon, distal colon, and rectum. Average annual percentage changes (AAPCs) in incidence and mortality were estimated and relevant patterns were descriptively analysed.In countries with long-standing programmes of screening colonoscopy and faecal tests (ie, Austria, the Czech Republic, and Germany), colorectal cancer incidence decreased substantially over time, with AAPCs ranging from -2·5 %F PUB:(DE-HGF)16 %9 Journal Article %$ pmid:34048685 %R 10.1016/S1470-2045(21)00199-6 %U https://inrepo02.dkfz.de/record/169018