TY - JOUR AU - Cardoso, Rafael AU - Guo, Feng AU - Heisser, Thomas AU - Hackl, Monika AU - Ihle, Petra AU - De Schutter, Harlinde AU - Van Damme, Nancy AU - Valerianova, Zdravka AU - Atanasov, Trajan AU - Májek, Ondřej AU - Mužík, Jan AU - Nilbert, Mef Christina AU - Tybjerg, Anne Julie AU - Innos, Kaire AU - Mägi, Margit AU - Malila, Nea AU - Bouvier, Anne-Marie AU - Bouvier, Véronique AU - Launoy, Guy AU - Woronoff, Anne-Sophie AU - Cariou, Mélanie AU - Robaszkiewicz, Michel AU - Delafosse, Patricia AU - Poncet, Florence AU - Katalinic, Alexander AU - Walsh, Paul M AU - Senore, Carlo AU - Rosso, Stefano AU - Vincerževskienė, Ieva AU - Lemmens, Valery E P P AU - Elferink, Marloes A G AU - Johannesen, Tom Børge AU - Kørner, Hartwig AU - Pfeffer, Frank AU - Bento, Maria José AU - Rodrigues, Jessica AU - Alves da Costa, Filipa AU - Miranda, Ana AU - Zadnik, Vesna AU - Žagar, Tina AU - Lopez de Munain Marques, Arantza AU - Marcos-Gragera, Rafael AU - Puigdemont, Montse AU - Galceran, Jaume AU - Carulla, Marià AU - Chirlaque, María-Dolores AU - Ballesta, Monica AU - Sundquist, Kristina AU - Sundquist, Jan AU - Weber, Marco AU - Jordan, Andrea AU - Herrmann, Christian AU - Mousavi, Mohsen AU - Ryzhov, Anton AU - Hoffmeister, Michael AU - Brenner, Hermann TI - Colorectal cancer incidence, mortality, and stage distribution in European countries in the colorectal cancer screening era: an international population-based study. JO - The lancet / Oncology VL - 22 IS - 7 SN - 1470-2045 CY - London PB - The Lancet Publ. Group M1 - DKFZ-2021-01186 SP - 1002-1013 PY - 2021 N1 - #EA:C120#LA:C070#/2021 Jul;22(7):1002-1013 AB - Colorectal cancer screening programmes and uptake vary substantially across Europe. We aimed to compare changes over time in colorectal cancer incidence, mortality, and stage distribution in relation to colorectal cancer screening implementation in European countries.Data from nearly 3·1 million patients with colorectal cancer diagnosed from 2000 onwards (up to 2016 for most countries) were obtained from 21 European countries, and were used to analyse changes over time in age-standardised colorectal cancer incidence and stage distribution. The WHO mortality database was used to analyse changes over time in age-standardised colorectal cancer mortality over the same period for the 16 countries with nationwide data. Incidence rates were calculated for all sites of the colon and rectum combined, as well as the subsites proximal colon, distal colon, and rectum. Average annual percentage changes (AAPCs) in incidence and mortality were estimated and relevant patterns were descriptively analysed.In countries with long-standing programmes of screening colonoscopy and faecal tests (ie, Austria, the Czech Republic, and Germany), colorectal cancer incidence decreased substantially over time, with AAPCs ranging from -2·5 LB - PUB:(DE-HGF)16 C6 - pmid:34048685 DO - DOI:10.1016/S1470-2045(21)00199-6 UR - https://inrepo02.dkfz.de/record/169018 ER -