% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Cardoso:169018,
      author       = {R. Cardoso$^*$ and F. Guo$^*$ and T. Heisser$^*$ and M.
                      Hackl and P. Ihle and H. De Schutter and N. Van Damme and Z.
                      Valerianova and T. Atanasov and O. Májek and J. Mužík and
                      M. C. Nilbert and A. J. Tybjerg and K. Innos and M. Mägi
                      and N. Malila and A.-M. Bouvier and V. Bouvier and G. Launoy
                      and A.-S. Woronoff and M. Cariou and M. Robaszkiewicz and P.
                      Delafosse and F. Poncet and A. Katalinic and P. M. Walsh and
                      C. Senore and S. Rosso and I. Vincerževskienė and V. E. P.
                      P. Lemmens and M. A. G. Elferink and T. B. Johannesen and H.
                      Kørner and F. Pfeffer and M. J. Bento and J. Rodrigues and
                      F. Alves da Costa and A. Miranda and V. Zadnik and T. Žagar
                      and A. Lopez de Munain Marques and R. Marcos-Gragera and M.
                      Puigdemont and J. Galceran and M. Carulla and M.-D.
                      Chirlaque and M. Ballesta and K. Sundquist and J. Sundquist
                      and M. Weber and A. Jordan and C. Herrmann and M. Mousavi
                      and A. Ryzhov and M. Hoffmeister$^*$ and H. Brenner$^*$},
      title        = {{C}olorectal cancer incidence, mortality, and stage
                      distribution in {E}uropean countries in the colorectal
                      cancer screening era: an international population-based
                      study.},
      journal      = {The lancet / Oncology},
      volume       = {22},
      number       = {7},
      issn         = {1470-2045},
      address      = {London},
      publisher    = {The Lancet Publ. Group},
      reportid     = {DKFZ-2021-01186},
      pages        = {1002-1013},
      year         = {2021},
      note         = {#EA:C120#LA:C070#/2021 Jul;22(7):1002-1013},
      abstract     = {Colorectal cancer screening programmes and uptake vary
                      substantially across Europe. We aimed to compare changes
                      over time in colorectal cancer incidence, mortality, and
                      stage distribution in relation to colorectal cancer
                      screening implementation in European countries.Data from
                      nearly 3·1 million patients with colorectal cancer
                      diagnosed from 2000 onwards (up to 2016 for most countries)
                      were obtained from 21 European countries, and were used to
                      analyse changes over time in age-standardised colorectal
                      cancer incidence and stage distribution. The WHO mortality
                      database was used to analyse changes over time in
                      age-standardised colorectal cancer mortality over the same
                      period for the 16 countries with nationwide data. Incidence
                      rates were calculated for all sites of the colon and rectum
                      combined, as well as the subsites proximal colon, distal
                      colon, and rectum. Average annual percentage changes (AAPCs)
                      in incidence and mortality were estimated and relevant
                      patterns were descriptively analysed.In countries with
                      long-standing programmes of screening colonoscopy and faecal
                      tests (ie, Austria, the Czech Republic, and Germany),
                      colorectal cancer incidence decreased substantially over
                      time, with AAPCs ranging from $-2·5\%$ $(95\%$ CI -2·8 to
                      -2·2) to $-1·6\%$ (-2·0 to -1·2) in men and from
                      $-2·4\%$ (-2·7 to -2·1) to $-1·3\%$ (-1·7 to -0·9) in
                      women. In countries where screening programmes were
                      implemented during the study period, age-standardised
                      colorectal cancer incidence either remained stable or
                      increased up to the year screening was implemented. AAPCs
                      for these countries ranged from $-0·2\%$ $(95\%$ CI -1·4
                      to 1·0) to $1·5\%$ (1·1 to 1·8) in men and from
                      $-0·5\%$ (-1·7 to 0·6) to $1·2\%$ (0·8 to 1·5) in
                      women. Where high screening coverage and uptake were rapidly
                      achieved (ie, Denmark, the Netherlands, and Slovenia),
                      age-standardised incidence rates initially increased but
                      then subsequently decreased. Conversely, colorectal cancer
                      incidence increased in most countries where no large-scale
                      screening programmes were available (eg, Bulgaria, Estonia,
                      Norway, and Ukraine), with AAPCs ranging from $0·3\%$
                      $(95\%$ CI 0·1 to 0·5) to $1·9\%$ (1·2 to 2·6) in men
                      and from $0·6\%$ (0·4 to 0·8) to $1·1\%$ (0·8 to 1·4)
                      in women. The largest decreases in colorectal cancer
                      mortality were seen in countries with long-standing
                      screening programmes.We observed divergent trends in
                      colorectal cancer incidence, mortality, and stage
                      distribution across European countries, which appear to be
                      largely explained by different levels of colorectal cancer
                      screening implementation.German Cancer Aid (Deutsche
                      Krebshilfe) and the German Federal Ministry of Education and
                      Research.},
      cin          = {C120 / C070 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)C120-20160331 / I:(DE-He78)C070-20160331 /
                      I:(DE-He78)HD01-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34048685},
      doi          = {10.1016/S1470-2045(21)00199-6},
      url          = {https://inrepo02.dkfz.de/record/169018},
}