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@ARTICLE{Cao:169051,
      author       = {J. Cao and W. Yan and X. Ma$^*$ and H. Huang and H. Yan},
      title        = {{I}nsulin-like growth factor 2 m{RNA}-binding protein 2 - a
                      potential link between type 2 diabetes mellitus and cancer.},
      journal      = {The journal of clinical endocrinology $\&$ metabolism},
      volume       = {106},
      number       = {10},
      issn         = {1945-7197},
      address      = {Oxford},
      publisher    = {Oxford University Press},
      reportid     = {DKFZ-2021-01209},
      pages        = {2807-2818},
      year         = {2021},
      note         = {2021 Sep 27;106(10):2807-2818},
      abstract     = {Type 2 diabetes mellitus (T2DM) and cancer share a variety
                      of risk factors and pathophysiological features. It is
                      becoming increasingly accepted that the two diseases are
                      related, and that T2DM increases the risk of certain
                      malignancies. This review summarizes recent advancements in
                      the elucidation of functions of insulin-like growth factor 2
                      (IGF-2) mRNA-binding protein 2 (IGF2BP2) in T2DM and
                      cancer.A PubMed review of the literature was conducted, and
                      search terms included: IGF2BP2, IMP2, or p62 in combination
                      with cancer or T2DM. Additional sources were identified
                      through manual searches of reference lists.The increased
                      risk of multiple malignancies and cancer-associated
                      mortality in patients with T2DM is believed to be driven by
                      insulin resistance, hyperinsulinemia, hyperglycemia, chronic
                      inflammation, and dysregulation of adipokines and sex
                      hormones. Furthermore, IGF-2 is oncogenic, and its
                      loss-of-function splice variant is protective against T2DM,
                      which highlights the pivotal role of this growth factor in
                      the pathogenesis of these two diseases. IGF-2 mRNA-binding
                      proteins, particularly IGF2BP2, are also involved in T2DM
                      and cancer, and single nucleotide polymorphisms of IGF2BP2
                      are associated with both diseases. Deletion of the IGF2BP2
                      gene in mice improves their glucose tolerance and insulin
                      sensitivity and mice with transgenic p62, a splice variant
                      of IGF2BP2, are prone to diet-induced fatty liver disease
                      and hepatocellular carcinoma, suggesting the biological
                      significance of IGF2BP2 in T2DM and cancer.Accumulating
                      evidence revealed that IGF2BP2 mediates the pathogenesis of
                      T2DM and cancer by regulating glucose metabolism, insulin
                      sensitivity, and tumorigenesis. This review provides insight
                      into the potential involvement of this RNA binding protein
                      in the link between T2DM and cancer.},
      subtyp        = {Review Article},
      keywords     = {IGF-2 mRNA-binding protein 2 (Other) / cancer (Other) /
                      inflammation (Other) / metabolism (Other) / type 2 diabetes
                      mellitus (Other)},
      cin          = {A240},
      ddc          = {610},
      cid          = {I:(DE-He78)A240-20160331},
      pnm          = {311 - Zellbiologie und Tumorbiologie (POF4-311)},
      pid          = {G:(DE-HGF)POF4-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34061963},
      doi          = {10.1210/clinem/dgab391},
      url          = {https://inrepo02.dkfz.de/record/169051},
}