%0 Journal Article
%A Xu, Xing
%A Kharazmi, Elhamalsadat
%A Tian, Yu
%A Mukama, Trasias
%A Sundquist, Kristina
%A Sundquist, Jan
%A Brenner, Hermann
%A Fallah, Mahdi
%T Risk of prostate cancer in relatives of prostate cancer patients in Sweden: A nationwide cohort study.
%J PLoS medicine
%V 18
%N 6
%@ 1549-1676
%C Lawrence, Kan.
%I PLoS
%M DKFZ-2021-01216
%P e1003616 -
%D 2021
%Z #EA:C120#LA:C120#
%X Evidence-based guidance for starting ages of screening for first-degree relatives (FDRs) of patients with prostate cancer (PCa) to prevent stage III/IV or fatal PCa is lacking in current PCa screening guidelines. We aimed to provide evidence for risk-adapted starting age of screening for relatives of patients with PCa.In this register-based nationwide cohort study, all men (aged 0 to 96 years at baseline) residing in Sweden who were born after 1931 along with their fathers were included. During the follow-up (1958 to 2015) of 6,343,727 men, 88,999 were diagnosed with stage III/IV PCa or died of PCa. The outcomes were defined as the diagnosis of stage III/IV PCa or death due to PCa, stratified by age at diagnosis. Using 10-year cumulative risk curves, we calculated risk-adapted starting ages of screening for men with different constellations of family history of PCa. The 10-year cumulative risk of stage III/IV or fatal PCa in men at age 50 in the general population (a common recommended starting age of screening) was 0.2
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:34061847
%R 10.1371/journal.pmed.1003616
%U https://inrepo02.dkfz.de/record/169058