TY  - JOUR
AU  - Xu, Xing
AU  - Kharazmi, Elhamalsadat
AU  - Tian, Yu
AU  - Mukama, Trasias
AU  - Sundquist, Kristina
AU  - Sundquist, Jan
AU  - Brenner, Hermann
AU  - Fallah, Mahdi
TI  - Risk of prostate cancer in relatives of prostate cancer patients in Sweden: A nationwide cohort study.
JO  - PLoS medicine
VL  - 18
IS  - 6
SN  - 1549-1676
CY  - Lawrence, Kan.
PB  - PLoS
M1  - DKFZ-2021-01216
SP  - e1003616 -
PY  - 2021
N1  - #EA:C120#LA:C120#
AB  - Evidence-based guidance for starting ages of screening for first-degree relatives (FDRs) of patients with prostate cancer (PCa) to prevent stage III/IV or fatal PCa is lacking in current PCa screening guidelines. We aimed to provide evidence for risk-adapted starting age of screening for relatives of patients with PCa.In this register-based nationwide cohort study, all men (aged 0 to 96 years at baseline) residing in Sweden who were born after 1931 along with their fathers were included. During the follow-up (1958 to 2015) of 6,343,727 men, 88,999 were diagnosed with stage III/IV PCa or died of PCa. The outcomes were defined as the diagnosis of stage III/IV PCa or death due to PCa, stratified by age at diagnosis. Using 10-year cumulative risk curves, we calculated risk-adapted starting ages of screening for men with different constellations of family history of PCa. The 10-year cumulative risk of stage III/IV or fatal PCa in men at age 50 in the general population (a common recommended starting age of screening) was 0.2
LB  - PUB:(DE-HGF)16
C6  - pmid:34061847
DO  - DOI:10.1371/journal.pmed.1003616
UR  - https://inrepo02.dkfz.de/record/169058
ER  -