%0 Journal Article
%A Hilvo, Mika
%A Dhar, Indu
%A Lääperi, Mitja
%A Lysne, Vegard
%A Sulo, Gehard
%A Tell, Grethe S
%A Jousilahti, Pekka
%A Nygård, Ottar K
%A Brenner, Hermann
%A Schöttker, Ben
%A Laaksonen, Reijo
%T Primary cardiovascular risk prediction by LDL-cholesterol in Caucasian middle-aged and older adults: a joint analysis of three cohorts.
%J European journal of preventive cardiology
%V 29
%N 3
%@ 2047-4881
%C London [u.a.]
%I Sage Publ.
%M DKFZ-2021-01218
%P e128-e137
%D 2022
%Z 2022 Mar 25;29(3):e128-e137
%X Low-density lipoprotein cholesterol (LDL-C) is an established causal driver of atherosclerotic cardiovascular disease (ASCVD), but its performance and age-dependency as a biomarker for incident events and mortality arising from ASCVD is less clear. The aim was to determine the value of LDL-C as a susceptibility/risk biomarker for incident coronary heart disease (CHD), ASCVD, and stroke events and deaths, for the age groups <50 and ≥50 years.The performance of LDL-C was evaluated in three cohorts, FINRISK 2002 (n = 7709), HUSK (n = 5431), and ESTHER (n = 4559), by Cox proportional hazards models, C-statistics, and net reclassification index calculations. Additionally, the hazard ratios (HRs) for the three cohorts were pooled by meta-analysis. The most consistent association was observed for CHD [95
%K Cholesterol (Other)
%K Guideline (Other)
%K LDL (Other)
%K Performance (Other)
%K Prediction (Other)
%K Risk (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:34060615
%R 10.1093/eurjpc/zwab075
%U https://inrepo02.dkfz.de/record/169060