TY  - JOUR
AU  - Hilvo, Mika
AU  - Dhar, Indu
AU  - Lääperi, Mitja
AU  - Lysne, Vegard
AU  - Sulo, Gehard
AU  - Tell, Grethe S
AU  - Jousilahti, Pekka
AU  - Nygård, Ottar K
AU  - Brenner, Hermann
AU  - Schöttker, Ben
AU  - Laaksonen, Reijo
TI  - Primary cardiovascular risk prediction by LDL-cholesterol in Caucasian middle-aged and older adults: a joint analysis of three cohorts.
JO  - European journal of preventive cardiology
VL  - 29
IS  - 3
SN  - 2047-4881
CY  - London [u.a.]
PB  - Sage Publ.
M1  - DKFZ-2021-01218
SP  - e128-e137
PY  - 2022
N1  - 2022 Mar 25;29(3):e128-e137
AB  - Low-density lipoprotein cholesterol (LDL-C) is an established causal driver of atherosclerotic cardiovascular disease (ASCVD), but its performance and age-dependency as a biomarker for incident events and mortality arising from ASCVD is less clear. The aim was to determine the value of LDL-C as a susceptibility/risk biomarker for incident coronary heart disease (CHD), ASCVD, and stroke events and deaths, for the age groups <50 and ≥50 years.The performance of LDL-C was evaluated in three cohorts, FINRISK 2002 (n = 7709), HUSK (n = 5431), and ESTHER (n = 4559), by Cox proportional hazards models, C-statistics, and net reclassification index calculations. Additionally, the hazard ratios (HRs) for the three cohorts were pooled by meta-analysis. The most consistent association was observed for CHD [95
KW  - Cholesterol (Other)
KW  - Guideline (Other)
KW  - LDL (Other)
KW  - Performance (Other)
KW  - Prediction (Other)
KW  - Risk (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:34060615
DO  - DOI:10.1093/eurjpc/zwab075
UR  - https://inrepo02.dkfz.de/record/169060
ER  -