%0 Journal Article
%A Hartmann, Benedikt
%A Müller, Max
%A Seyler, Lisa
%A Bäuerle, Tobias
%A Wilferth, Tobias
%A Avdievitch, Nikolai
%A Ruhm, Loreen
%A Henning, Anke
%A Lesiv, Alexei
%A Ivashkin, Pavel
%A Uder, Michael
%A Nagel, Armin
%T Feasibility of deuterium magnetic resonance spectroscopy of 3-O-Methylglucose at 7 Tesla.
%J PLOS ONE
%V 16
%N 6
%@ 1932-6203
%C San Francisco, California, US
%I PLOS
%M DKFZ-2021-01269
%P e0252935 -
%D 2021
%Z #LA:E020#
%X Deuterium Magnetic Resonance Spectroscopy (DMRS) is a non-invasive technique that allows the detection of deuterated compounds in vivo. DMRS has a large potential to analyze uptake, perfusion, washout or metabolism, since deuterium is a stable isotope and therefore does not decay during biologic processing of a deuterium labelled substance. Moreover, DMRS allows the distinction between different deuterated substances. In this work, we performed DMRS of deuterated 3-O-Methylglucose (OMG). OMG is a non-metabolizable glucose analog which is transported similar to D-glucose. DMRS of OMG was performed in phantom and in vivo measurements using a preclinical 7 Tesla MRI system. The chemical shift (3.51 ± 0.1 ppm) and relaxation times were determined. OMG was injected intravenously and spectra were acquired over a period of one hour to monitor the time evolution of the deuterium signal in tumor-bearing rats. The increase and washout of OMG could be observed. Three different exponential functions were compared in terms of how well they describe the OMG washout. A mono-exponential model with offset seems to describe the observed time course best with a time constant of 1910 ± 770 s and an offset of 2.5 ± 1.2 mmol/l (mean ± std, N = 3). Chemical shift imaging could be performed with a voxel size of 7.1 mm x 7.1 mm x 7.9 mm. The feasibility of DMRS with deuterium labelled OMG could be demonstrated. These data might serve as basis for future studies that aim to characterize glucose transport using DMRS.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:34097707
%R 10.1371/journal.pone.0252935
%U https://inrepo02.dkfz.de/record/169124