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000169124 1001_ $$00000-0003-3580-7827$$aHartmann, Benedikt$$b0
000169124 245__ $$aFeasibility of deuterium magnetic resonance spectroscopy of 3-O-Methylglucose at 7 Tesla.
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000169124 520__ $$aDeuterium Magnetic Resonance Spectroscopy (DMRS) is a non-invasive technique that allows the detection of deuterated compounds in vivo. DMRS has a large potential to analyze uptake, perfusion, washout or metabolism, since deuterium is a stable isotope and therefore does not decay during biologic processing of a deuterium labelled substance. Moreover, DMRS allows the distinction between different deuterated substances. In this work, we performed DMRS of deuterated 3-O-Methylglucose (OMG). OMG is a non-metabolizable glucose analog which is transported similar to D-glucose. DMRS of OMG was performed in phantom and in vivo measurements using a preclinical 7 Tesla MRI system. The chemical shift (3.51 ± 0.1 ppm) and relaxation times were determined. OMG was injected intravenously and spectra were acquired over a period of one hour to monitor the time evolution of the deuterium signal in tumor-bearing rats. The increase and washout of OMG could be observed. Three different exponential functions were compared in terms of how well they describe the OMG washout. A mono-exponential model with offset seems to describe the observed time course best with a time constant of 1910 ± 770 s and an offset of 2.5 ± 1.2 mmol/l (mean ± std, N = 3). Chemical shift imaging could be performed with a voxel size of 7.1 mm x 7.1 mm x 7.9 mm. The feasibility of DMRS with deuterium labelled OMG could be demonstrated. These data might serve as basis for future studies that aim to characterize glucose transport using DMRS.
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000169124 7001_ $$aMüller, Max$$b1
000169124 7001_ $$aSeyler, Lisa$$b2
000169124 7001_ $$aBäuerle, Tobias$$b3
000169124 7001_ $$aWilferth, Tobias$$b4
000169124 7001_ $$aAvdievitch, Nikolai$$b5
000169124 7001_ $$aRuhm, Loreen$$b6
000169124 7001_ $$aHenning, Anke$$b7
000169124 7001_ $$aLesiv, Alexei$$b8
000169124 7001_ $$aIvashkin, Pavel$$b9
000169124 7001_ $$aUder, Michael$$b10
000169124 7001_ $$0P:(DE-He78)054fd7a5195b75b11fbdc5c360276011$$aNagel, Armin$$b11$$eLast author$$udkfz
000169124 773__ $$0PERI:(DE-600)2267670-3$$a10.1371/journal.pone.0252935$$gVol. 16, no. 6, p. e0252935 -$$n6$$pe0252935 -$$tPLOS ONE$$v16$$x1932-6203$$y2021
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